Protein Kinase C in Cancer Signaling and Therapy

Regulation of PKC Isozyme Function: From Genes to Biochemistry.- Protein Kinase C in Cancer Signaling and Therapy: Introduction and Historical Perspective.- Regulation of Conventional and Novel Protein Kinase C Isozymes by Phosphorylation and Lipids.- Phorbol Esters and Diacylglycerol: The PKC Activators.- Diacylglycerol Signaling: The C1 Domain, Generation of DAG, and Termination of Signals.- Regulation of PKC by Protein–Protein Interactions in Cancer.- PKC Isozymes in the Control of Cell Function.- Introduction: PKC Isozymes in the Control of Cell Function.- Regulation and Function of Protein Kinase D Signaling.- PKC and Control of the Cell Cycle.- PKC and the Control of Apoptosis.- Atypical PKCs, NF-?B, and Inflammation.- PKC Isozymes in Cancer.- Introduction: PKC and Cancer.- Protein Kinase C, p53, and DNA Damage.- PKCs as Mediators of the Hedgehog and Wnt Signaling Pathways.- PKC–PKD Interplay in Cancer.- Transgenic Mouse Models to Investigate Functional Specificity of Protein Kinase C Isoforms in the Development of Squamous Cell Carcinoma, a Nonmelanoma Human Skin Cancer.- PKC Isozymes and Skin Cancer.- PKC and Breast Cancer.- PKC and Prostate Cancer.- Protein Kinase C and Lung Cancer.- PKC Isozymes as Targets for Cancer Therapy.- PKC and Resistance to Chemotherapeutic Agents.- PKC? as a Target for Chemotherapeutic Drugs.- Atypical PKCs as Targets for Cancer Therapy.