Essentials of Diagnostic Breast Pathology (eBook)

Dedication 5
Preface 6
Contents 8
Abbreviations 11
The Normal Breast 12
Contents 12
CHAPTER 1 The Normal Breast 13
1.2 Pregnancy and Lactation 13
1.1 Anatomy 13
1.3 Menopause 14
1.4 Immunoprofile 14
1.5 Further Reading 14
Specimen Processing 17
Contents 17
CHAPTER 2 Specimen Processing 18
2.1 Frozen Section 18
2.2 Core Needle Biopsy 19
2.3 Excisional Biopsy Caution 20
2.4 Mastectomy 21
2.5 Axillary Lymph Nodes 21
2.6 Sentinel Lymph Nodes 22
2.7 Further Reading 22
Fibrocystic Change and Duct Ectasia 24
Contents 24
CHAPTER 3 Fibrocystic Change and Duct Ectasia 25
3.1 Fibrocystic Change 25
3.2 Duct Ectasia (Periductal Mastitis) 26
Adenosis 34
Contents 34
CHAPTER 4 Adenosis 35
4.1 Definition, Types, and Macroscopy of Adenosis 35
4.2 Blunt Duct Adenosis 35
4.3 Sclerosing Adenosis 36
4.4 Apocrine Adenosis ( Adenosis with Apocrine Metaplasia) 37
4.5 Tubular Adenosis 38
4.6 Adenomyoepithelial Adenosis 38
4.7 Microglandular Adenosis 39
4.8 Radial Scar/Complex Sclerosing Lesion 39
4.9 Collagenous Spherulosis 41
Intraductal Proliferative Lesions 73
Contents 73
CHAPTER 5 Intraductal Proliferative Lesions 74
5.1 Usual Ductal Hyperplasia 74
5.2 Ductal Intraepithelial Neoplasia (DIN) 76
5.3 Ductal Intraepithelial Neoplasia (DIN), Flat Type 78
5.4 Low-Grade Ductal Intraepithelial Neoplasia ( WHO: DIN1b Atypical Ductal Hyperplasia)
5.5 Ductal Intraepithelial Neoplasia ( WHO: DIN1c– DIN3, DCIS) 82
Intraductal Papillary Neoplasms 128
Contents 128
CHAPTER 6 Intraductal Papillary Neoplasms 129
6.1 Central Papilloma 129
6.2 Peripheral Papilloma 129
6.3 Sclerosing Papilloma 130
6.4 Intraductal Papillary Carcinoma ( Papillary Ductal Intraepithelial Neoplasia) 130
6.5 Role of Immunohistochemistry in Diagnosing Intraductal Papillary Neoplasms 131
6.6 Additional Comments 131
6.7 Further Reading 132
Lobular Intraepithelial Neoplasia ( LIN) 159
Contents 159
CHAPTER 7 Lobular Intraepithelial Neoplasia ( LIN) 160
7.1 Synonyms 160
7.2 Background 160
7.3 Microscopic Features 160
7.4 Additional Comments 160
7.5 Further Reading 161
Infiltrating Ductal Carcinoma ( NOS Type) 181
Contents 181
CHAPTER 8 Infiltrating Ductal Carcinoma ( NOS Type) 182
8.1 Definition 182
8.2 Macroscopy 182
8.3 Microscopic Features 182
8.4 Grading 182
8.5 Additional Comments 183
8.6 Further Reading 183
Invasive Lobular Carcinoma ( ILC) 191
Contents 191
CHAPTER 9 Invasive Lobular Carcinoma (ILC) 192
9.1 Macroscopy 192
9.2 Microscopic Features 192
9.3 Additional Comments 192
9.4 Immunohistochemistry of LIN and ILC 192
9.5 Grading 192
9.6 Further Reading 193
Special Types of Breast Carcinomas 220
Contents 220
CHAPTER 10 Special Types of Breast Carcinomas 222
10.1 Tubular Carcinoma 222
10.2 Mucin-Producing Carcinomas of the Breast 223
10.3 Carcinoma with Neuroendocrine Differentiation 225
10.4 Invasive Papillary Carcinoma 226
10.5 Invasive Micropapillary Carcinoma 226
10.6 Apocrine Carcinoma 227
10.7 Secretory Carcinoma 228
10.8 Adenoid Cystic Carcinoma 229
10.9 Acinic Cell Carcinoma 230
10.10 Sebaceous Carcinoma 231
10.11 Infiltrating Cribriform Carcinoma 231
10.12 Medullary Carcinoma 232
10.13 Metaplastic Carcinomas 233
10.14 Clear Cell (Glycogen-Rich) Carcinoma 236
10.15 Lipid-Rich Carcinoma ( Lipid- Secreting Carcinoma) 237
10.16 Metastatic Carcinoma 237
10.17 Inflammatory Carcinoma 238
Biphasic Tumors 316
Contents 316
CHAPTER 11 Biphasic Tumors 317
11.1 Fibroadenoma 317
11.2 Phylloides Tumor 318
Diseases of the Nipple 347
Contents 347
CHAPTER 12 Disease of the Nipple 348
12.1 Paget’s Disease 348
12.2 Nipple Duct Adenoma 349
12.3 (Infiltrating) Syringomatous Adenoma 350
Male Breast Lesions 360
Contents 360
CHAPTER 13 Male Breast Lesions 361
13.1 Gynecomastia 361
13.2 Papilloma 362
13.3 Primary Male Breast Carcinoma 362
13.4 Further Reading 362
Mesenchymal Lesions/ Tumors 369
Contents 369
CHAPTER 14 Mesenchymal Lesions/Tumors 371
14.1 Stromal Elastosis 371
14.2 Fat Necrosis 371
14.3 Metaplasias 372
14.4 Pseudoangiomatous Stromal Hyperplasia 372
14.5 Fibromatosis 373
14.6 Myofibroblastoma 374
14.7 Lipoma 375
14.8 Angiolipoma 375
14.9 Granular Cell Tumor 376
14.10 Hamartoma 377
14.11 Perilobular Hemangioma 377
14.12 Hemangioma 378
14.13 Angiomatosis 378
14.14 Angiosarcoma 379
14.15 Leiomyosarcoma 380
14.16 Liposarcoma 381
14.17 Rhabdomyosarcoma 381
14.18 Malignant Fibrous Histiocytoma 382
14.19 Osteosarcoma 383
14.20 Spindle Cell Sarcoma, Not Otherwise Specified ( NOS- Type Mammary Sarcoma) 383
Myoepithelial Lesions/ Neoplasms 401
Contents 401
CHAPTER 15 Myoepithelial Lesions/Neoplasms 402
15.1 Background 402
15.2 Immunoprofile 402
15.3 Myoepithelial Cell Hypertrophy 402
15.4 Myoepitheliosis (Myoepithelial Hyperplasia) 402
15.5 Adenomyoepithelioma 403
15.6 Sarcomatoid Carcinoma with Myoepithelial Differentiation ( Myoepithelial Carcinoma, Malignant Myoepithelioma) 404
Miscellaneous Lesions 410
Contents 410
CHAPTER 16 Miscellaneous Lesions 411
16.1 Acute Mastitis (Puerperal Mastitis) 411
16.2 Subareolar Abscess 411
16.3 Plasma Cell Mastitis 411
16.4 Idiopathic Granulomatous Mastitis 412
16.5 Lymphocytic Mastitis (Diabetic Mastopathy) 412
16.6 Eosinophilic Mastitis 413
16.7 Silicone Mastitis and Diseases Associated with Cosmetic Augmentation 413
16.8 Further Reading 413
16.9 Pathologic Effects of Adjuvant Radiotherapy 414
16.10 Pathologic Effects of ( Neo) adjuvant Chemotherapy 414
16.11 Malignant Lymphoma 415
16.12 Diffuse Large B-Cell Lymphoma 415
16.13 Burkitt’s Lymphoma 416
16.14 Extranodal Marginal-Zone B-Cell Lymphoma of MALT Type 416
16.15 Follicular Lymphoma 416
Cytopathology of Benign and Malignant Lesions ( Selected Topics) 428
Contents 428
CHAPTER 17 Cytopathology of Benign and Malignant Lesions ( Selected Topics) 429
17.1 Introduction 429
17.2 Fibrocystic Change 429
17.3 Proliferative Breast Diseases Without Atypia(Adenosis, Ductal Hyperplasia Fig. 105)
17.4 Proliferative Breast Lesions with Atypia 429
17.5 Lactating Adenoma and Lactating Changes 430
17.6 Fibroadenoma 430
17.7 Intraductal Papilloma 430
17.8 Ductal Intraepithelial Neoplasia(Ductal Carcinoma In Situ) 430
17.9 Lobular Intraepithelial Neoplasia 431
17.10 Intraductal Papillary Carcinoma 431
17.11 Infiltrating Ductal Carcinoma 431
17.12 Infiltrating Lobular Carcinoma 431
17.13 Tubular Carcinoma 432
17.14 Mucinous Carcinoma 432
17.15 Medullary Carcinoma 432
17.16 Apocrine Carcinoma 432
17.17 Adenoid Cystic Carcinoma 432
17.18 Metaplastic (Sarcomatoid) Carcinoma 433
17.19 Phylloides (Phyllodes) Tumor 433
17.20 Further Reading 433
Immunohistochemistry ( Selected Topics) 459
Contents 459
CHAPTER 18 Immunohistochemistry ( Selected Topics) 460
18.1 Role of Immunohistochemistry in Diagnostic Breast Pathology 460
18.2 Immunohistochemistry in the Differential Diagnosis of Epithelial Lesions: Myoepithelial Cells 460
18.3 Carcinomas with Myoepithelial Differentiation Versus Primary Sarcoma 461
18.4 Microinvasive Carcinoma 461
18.5 Cell Population in Intraductal Proliferative Lesions: Homogeneous Versus Heterogeneous Cell Population ( Neoplasia Versus Hyperplasia) 461
18.6 Paget’s Disease 462
18.7 Distinction Between DIN (DCIS) and LIN (LCIS) 462
18.8 Systemic Metastasis of Breast Carcinoma 462
18.9 Micrometastatic Disease in Axillary Lymph Nodes ( Including Sentinel Nodes) 462
18.10 Immunohistochemistry for Prognostic or Predictive Factors in Breast Carcinoma: Hormone Receptors 463
18.11 HER2/neu Overexpression 463
18.12 Further Reading 463
Subject Index 480