Serotonin Receptors (eBook)

Preface 6
Contents 9
Contributors 12
Color Plate 16
Molecular Biology and Genomic Organization of G Protein– Coupled Serotonin Receptors 17
Structure and Function Reveal Insights in the Pharmacology of 5- HT Receptor Subtypes 55
Polymorphic and Posttranscriptional Modifications of 5- HT Receptor Structure 75
Strategies for the Development of Selective Serotonergic Agents 107
5-HT Receptor Signal Transduction Pathways 159
Agonist-Directed Trafficking of 5-HT Receptor- Mediated Signal Transduction 223
Identification of 5- HT2 and 5-HT4 Receptor- Interacting Proteins 252
5-HT Receptor-Associated Proteins (FRAPs) 275
Cellular and Subcellular Localization of Serotonin Receptors in the Central Nervous System 295
Chemical Neuroanatomy of 5-HT Receptor Subtypes in the Mammalian Brain 336
Modulation of the Neuronal Activityand Neurotransmitter Release by 5-HT1Aand 5-HT1B/1D Receptors 382
Electrophysiology of 5- HT2A Receptors and Relevance for Hallucinogen and Atypical Antipsychotic Drug Actions 419
The Emergence of 5- HT2B Receptors as Targets to Avoid in Designing and Refining Pharmaceuticals 434
The 5- HT3 Receptor 454
5- HT3 and 5-HT4 Receptors as Targets for Drug Discovery for Dementia 473
Electrophysiological Propertiesof Gas-Coupled 5-HT Receptors(5-HT4, 5-HT6, 5-HT7) 494
5- HT6 Receptors as Targets for the Treatment of Cognitive Deficits in Schizophrenia 508
5- HT7 Receptors as Favorable Pharmacological Targets for Drug Discovery 529
Serotonin System Gene Knockouts 548
Effects of Serotonin-Related Gene Deletion on Measures of Anxiety, Depression, and Neurotransmission 587
Index 617