Nutrition in Epigenetics

Mihai D. Niculescu is an Assistant Professor of Nutrition at the University of North Carolina's Gillings School of Global Public Health in Chapel Hill, and at the UNC Nutrition Research Institute in Kannapolis, North Carolina, USA. Paul Haggarty is Head of the Lifelong Health Programme, and the Nutrition and Epigenetics Group, at the Rowett Institute of Nutrition and Health in the University of Aberdeen in Aberdeen, Scotland.

Contributors. 1. Introduction ( Mihai D. Niculescu and Paul Haggarty). PART I: Fundamental Principles in Epigenetics. SECTION A: Epigenetic Mechanisms. 2. DNA Methylation ( Natalia V. Cucu). 3. Chromatin Modifications ( Sandra B. Hake). 4. Roles of RNAi and Other MicroRNAs in the Regulation of Epigenetic Processes ( Muller Fabbri). 5. Epigenetic Inheritance: Both Mitotic and Meiotic ( Nina J. Kaminen-Ahola, Arttu I. Ahola, and Emma Whitelaw). SECTION B: Development Epigenetics. 6. Developmental Epigenetics: Roles in Embryonic Development ( Liliana Burliba s a and Lucian Gavril a ). SECTION C: Epigenetic Mechanisms in Disease. 7. Epigenetics, Nutrition, and Cancer ( Amy R. Johnson). 8. Metabolic Syndrome, Obesity, and Diabetes ( Karen D. Corbin). 9. Autoimmunity ( Donna Ray and Raymond Yung). 10. Cardiovascular Diseases ( Aurelian Bidulescu and Methode Bacanamwo). PART II: Nutritional Status and Specific Nutrients. SECTION A: Maternal Nutrition and Fetal Development. 11. Maternal Nutrition and Developmental Outcomes ( Shannon L. Haley, Laurie J. Moyer-Mileur, Robert H. Lane, and Lisa A. Joss-Moore). SECTION B: Role of Specific Nutrients. 12. Folate, Vitamin B 12 , and Vitamin B 6 ( Patrick J. Stover). 13. Dietary Choline, Betaine, Methionine, and Epigenetic Mechanisms Influencing Brain Development ( Steven H. Zeisel). 14. Epigenetic Regulation by Retinoids ( Amandio Vieira). 15. We are WhatWe Eat: How Nutritional Compounds Such As Isoflavones Shape Our Epigenome ( Carlos M. Guerrero-Bosagna and Susan J. Clark). 16. Isothiocyanates and Polyphenols ( Nigel J. Belshaw and Ian T. Johnson). SECTION C: Macronutrient Intakes. 17. The Effect of Maternal Macronutrient Intake on Phenotype Induction and Epigenetic Gene Regulation ( Karen A. Lillycrop, Mark A. Hanson, and Graham C. Burdge). SECTION D: Environmental Exposures. 18. Epigenetic Manifestation of Environmental Exposures ( Dana C. Dolinoy, Olivia S. Anderson, and Laura S. Rozek). SECTION E: Epidemiology of Nutritional Epigenetics. 19. Epigenetics, Nutrition, and Reproduction: Short- and Long-Term Consequences ( Paul Haggarty). 20. Nutrition, Epigenetics, and Cancer: An Epidemiological Perspective ( Audrey Jung and Ellen Kampman). Index.