Practical Manual of Gastroesophageal Reflux Disease

Marcelo F. Vela, MD, MSCR, Associate Professor of Medicine, is the director of the gastrointestinal motility program at Baylor Clinic and the Michael E. DeBakey Veteran Affairs Medical Center, Houston, TX, USA. Dr. Vela is a nationally recognized specialist in esophageal diseases, swallowing disorders, and gastrointestinal motility. Dr John E. Pandolfino is Assistant Professor, Division of Gastroenterology at Northwestern University, Chicago, IL, USA. Dr Pandolfino has published extensively on gastrointestinal complications in surgery, pH monitoring of esophageal acid exposure, clinical use of esophageal manometry, and therapies and management of disorders of gastrointestinal motility. His research interests include esophageal physiology, gastroesophageal reflux disease, swallowing disorders, and esophageal diseases. Joel E Richter MD is Richard L Evans Professor and Chair, Department of Medicine, Temple University School of Medicine, Philadelphia, PA, USA. He specializes in the diagnosis and management of, and performs clinical research on, esophageal diseases including Barrett's oesophagus, GERD (including its extraesophageal presentation), achalasia and other motility disorders, non-cardiac chest pain, dysphagia and the effects that H. pylori has on the oesophagus. He has published more than 500 articles, chapters and books. He is the current co-Editor-in-Chief of the American Journal of Gastroenterology and past President of the American College of Gastroenterology and World Organization for Specialized Studies on Diseases of the Esophagus. Dr Richter has 338 articles on PubMed, and is editor of the following books: Ambulatory Esophageal Ph Monitoring: Practical Approach and Clinical Applications; Dysphagia: Diagnosis and Treatment; Gerd: Current Issues and Controversies; Textbook of Clinical Gastroenterology and Hepatology, 2nd edition (May 2012); The Esophagus, 5th edition (published March 2012).

List of Contributors, vii

Preface, ix

Part 1: Gastroesophageal Reflux Disease Overview, 1

1 Gastroesophageal Reflux Disease: Pathophysiology, 3
Pim W. Weijenborg, Boudewijn F. Kessing, and André J.P.M. Smout

2 Gastroesophageal Reflux Disease: Epidemiology, Impact on Quality of Life, and Health Economic Implications, 26
Nimish Vakil

3 Overview of the Tools for the Diagnosis of Gastroesophageal Reflux Disease, 39
Nicolas A. Villa and Marcelo F. Vela

4 Overview of Gastroesophageal Reflux Disease Treatments, 53
Sabine Roman and Peter J. Kahrilas

5 Gastroesophageal Reflux Disease Treatment: Side-Effects and Complications of Acid Suppression, 69
David A. Johnson

6 Gastroesophageal Reflux Disease Treatment: Side-Effects and Complications of Fundoplication, 83
Joel E. Richter

Part 2: Gastroesophageal Reflux Disease: Management of Specific Clinical Presentations, 97

7 Evaluation and Management of Refractory Gastroesophageal Reflux Disease, 99
John E. Pandolfino and Sabine Roman

8 Functional Heartburn, 115
Stanislas Bruley des Varannes, Frank Zerbib, and Jean-Paul Galmiche

9 The Role of Acid Reflux in Non-Cardiac Chest Pain, 132
Cristina Almansa and Sami R. Achem

10 Laryngopharyngeal Reflux, 154
Robert T. Kavitt and Michael F. Vaezi

11 Reflux-Related Cough, 179
Etsuro Yazaki, Ryuichi Shimono, and Daniel Sifrim

12 Relationship between Gastroesophageal Reflux Disease and Sleep, 195
Tiberiu Hershcovici and Ronnie Fass

13 Aerophagia and Belching, 221
Albert J. Bredenoord

14 Dysphagia and Gastroesophageal Reflux Disease, 239
Donald O. Castell and Erick R. Singh

15 Eosinophilic Esophagitis: Interactions with Gastroesophageal Reflux Disease, 253
Kumar Krishnan and Ikuo Hirano

16 Helicobacter pylori and Gastroesophageal Reflux Disease, 267
Maria Pina Dore and David Y. Graham

Part 3: Barrett ’ s Esophagus, 287

17 Barrett ’ s Esophagus: Diagnosis and Surveillance, 289
Gary W. Falk

18 Barrett ’ s Esophagus: Treatment Options, 310
Jianmin Tian and Kenneth K. Wang

Index, 335

Color plate section can be found facing page 118