UICC Manual of Clinical Oncology

Brian O'Sullivan is a Professor in the Department of Radiation Oncology at the University of Toronto, Toronto, Ontario, Canada. He also holds the Bartley-Smith/Wharton Distinguished Chair in Radiation Oncology in the Department of Radiation Oncology at the Princess Margaret Cancer Centre, University of Toronto. He is the Head and Neck Oncology Program Chair at Princess Margaret Cancer Centre, the co-Chair of the US NCI Head and Neck Steering Committee, Coordinating Center for Clinical Trials, CTEP, and a full standing member of the Commission of the International Commission on Radiation Units (ICRU). He is the recipient of numerous international awards, and research grants. He has published almost 300 peer reviewed papers, in excess of 50 book chapters, and has written or edited 6 oncology textbooks. His interests include sarcoma and head and neck cancer, translational research, IMRT delivery and the principles of image guided radiotherapy, chemo-radiotherapy and molecular targeting. He is a member of the TNM Committee of the Union for International Cancer Control (UICC), Chair of the UICC Prognostic Classification Sub-Committee and represents the UICC as liaison in several oncology sites to the American Joint Committee on Cancer (AJCC).

Raphael Pollock, M.D., Ph.D. was born in Chicago, Illinois and graduated from Oberlin College, Oberlin, Ohio in 1972. This was followed by medical school at the St. Louis University School of Medicine Chicago, IL residencies in General Surgery at the University of Chicago and Rush Medical College, a fellowship in Surgical Oncology at The University of Texas M. D. Anderson Cancer Center, and a Ph.D. in Tumor Immunology from the Graduate School of the Biological Sciences at the University of Texas-Houston Health Sciences Center. Dr. Pollock joined the Department of Surgical Oncology at The University of Texas M. D. Anderson Cancer Center as a faculty member in 1984. Dr. Pollock became Chairman of the Department of Surgical Oncology in 1993 and became Head of the Division of Surgery at The University of Texas M. D. Anderson Cancer Center in 1997. In 2006-07 Dr. Pollock served as President of the Society of Surgical Oncology; from 1999-2011 he served as Editor-in-Chief of Cancer. In 2013 Dr. Pollock left MD Anderson to become Director and Professor, Division of Surgical Oncology and Chief of Surgical Services at The James Comprehensive Cancer Center at The Ohio State University Medical Center, Columbus, Ohio. Dr. Pollock serves as Director of the Sarcoma Research Laboratory at The Ohio State University Medical Center and is the Principal Investigator on behalf of the US NIH/NCI SARC Sarcoma SPORE grant program. Dr. Pollock is a member of the US NIH/NCI Board of Scientific Counselors.

Foreword
Preface
About the Editors
Contributors
Residual tumor (R) classification
Part 1 General principles of cancer diagnosis and management
Principles of management
1 Cancer epidemiology Rajesh Dikshit and Preetha Rajaraman [M1]
2 Levels of evidence, guidelines and standards R. Bryan Rumble and Melissa C. Brouwers
3 Prognosis and classification of cancer Brian O'Sullivan, James Brierley and Mary Gospodarowicz
4 Principles of cancer staging Leslie Sobin, James Brierley, Mary Gospodarowicz, Brian O Sullivan and Christian Wittekind
5 Assessment of treatment outcome Judi Manola, Wei Xu and Bruce J. Giantonio
6 Cancer informatics David Jaffray, Andrew Hope, Terry Michaelson, Prateek Dwivedi and Andre Dekker

Principles of cancer diagnosis
7 Imaging Supreeta Arya, Venkatesh Rangarajan and Nilendu Purandare
8 Pathology Joanna Chan, Rossitza Draganova-Tacheva, Wei Jiang, Zi-Xuan Wang and Stephen Peiper

Principles of treatment
9 Principles of surgery Matthew Katz and Brian Bednarski
10 Principles of radiotherapy Vincent Gregoire, Cai Grau, Karin Haustermans, Ludvig Paul Muren and Fiona Stewart
11 Principles of systemic therapy Martin F. Fey and Stefan Aebi

Special settings, supportive care and survivorship
12 Treatment in pregnancy Hatem A. Azim, Fedro A. Peccatori, Isabel Demeestere, Oreste Gentilini and Nicholas Pavlidis
13 Treatment in the elderly Matti Aapro
14 Oncology emergencies Jonathan King, Dustin Deming and H. Ian Robins
15 Supportive care during curative treatment Susan Urba, Suzette Walker, Danielle Karsies, Dawna Allore, Claire Casselman and Maria Almond
16 Pain management P. N. Jain and Sumitra Bakshi
17 Palliative care Mary Ann Muckaden
18 Survivorship Jennifer M. Jones, Felicia Knaul, Meredith Giuliani, Danielle Rodin and Pamela Catton 19 Rehabilitation Theresa Gillis and Kerry Tobias

Part 2
Site-specific multidisciplinary cancer management
Thoracic malignancies
20 Lung Suresh S. Ramalingam, Felix Fernandez, Kristin A. Higgins, William F. Auffermann and Fadlo R. Khuri

Breast
21 Breast Ivo A. Olivotto, Caroline Lohrisch and Christopher Baliski

Gastrointestinal malignancies
22 Liver Eddie K. Abdalla, Emile Brihi and Hady Ghanem
23 Biliary tract and pancreas
23.1 Biliary tract Rory L. Smoot, Christopher L. Hallemeier,Robert R. McWilliams and Mark J. Truty 23.2 Pancreas Rory L. Smoot, Christopher L. Hallemeier,Robert R. McWilliamsand Mark J. Truty
24 Oesophagus Wentao Fang, Zhigang Li, Teng Mao, Jun Liu and Xufeng Guo
25 Stomach Takeshi Sano, Savtaj Brar, James Brierley and Jan Vermorken
26 Colon, rectum and anus
26.1 Colon and rectum Rob Glynne-Jones, Gina Brown, Ian Chau and Brendan J. Moran 26.2 Anus Rob Glynne-Jones, Gina Brown, Ian Chau and Brendan J. Moran G

Genitourinary malignancies
27 Prostate Malcolm Mason, Howard Kynaston and Robert Jones
28 Bladder and other urothelium Gillian M. Duchesne, Shomik Sengupta and Ian D. Davis
29 Kidney J. E. Ferguson III, W. Kimryn Rathmell and Eric M. Wallen
30 Testis Christian Winter, Anja Lorch, Carsten Bokemeyer, Heinz Schmidberger and Peter Albers
31 Penis Juanita Crook, Lance Pagliaro and Curtis Pettaway

Haematological malignancies
32 Lymphoma Richard W. C. Tsang and Michael Crump
33 Myeloma J. San Miguel, P. Rodriguez-Otero , E. Ocio, B. Paiva, N. Gutierrez and M. V. Mateos
34 Leukaemia Tsila Zuckerman and Jacob M. Rowe Gynaecological cancers
35 Cervix Lynette Denny and Leon Van Wijk
36 Uterus G. Kristensen, V. Abeler, Kristina Lindemann and Carien L. Creutzberg 37 Ovary and fallopian tube Gemma Owens and Henry Kitchener
38 Vulva M. H. M. Oonk, E. Pras and A. G. J. van der Zee

Head and neck cancer
39 General principles of head and neck cancer management Mitali Dandekar, Anil K. D Cruz, Shao Hui Huang, Brian O Sullivan and Jan B. Vermorken
40 Nasopharynx Ann W. M. Lee, W. T. Ng, Quynh-Thu Le, Anthony T. C. Chan, Jimmy Y. W. Chan and Henry C. K. Sze
41 Oral cavity Richa Vaish, Mitali Dandekar, Jai Prakash Agarwal, Kumar Prabhash and Anil K. D'Cruz
42 Larynx and hypopharynx Jai Prakash Agarwal, Tejpal Gupta, Rahul Krishnatry, Amit Joshi and Mitali Dandekar
43 Oropharynx Shao Hui Huang, Hisham Mehanna, Jan B. Vermorken and Brian O'Sullivan
44 Major salivary glands Devendra Chaukar, Abhishek D. Vaidya, Rohan Walvekar, Sarbani Ghosh-Laskar and Kumar Prabhash
45 Nasal cavity and paranasal sinus Prathamesh S. Pai, Sarbani Ghosh-Laskar, Shubhada Kane, K. Thomas Robbins, Piero Nicolai and Lisa Licitra
46 Head and neck unknown primary Sarbani Ghosh-Laskar, Naveen B. Mummudi, Vedang Murthy and Gouri Pantvaidya

Endocrine tumours
47 Pituitary Sherise D. Ferguson and Ian E. McCutcheon
48 Thyroid James D. Brierley, David P. Goldstein and Monika K. Krzyzanowska
49 Adrenal gland Minerva Angelica Romero Arentumouras, Mouhammed Amir Habra and Nancy D. Perrier
50 Neuroendocrine tumours Dermot O'Toole, Laura H. Tang, Robert T. Jensen, Massimo Falconi, U.-F. Pape and Dik Kwekkeboom

Dermatological cancer
51 Skin: Basal cell carcinoma, squamous cell carcinoma and Merkel cell carcinoma Sandro V. Porceddu, Michael J. Veness and H. Peter Soyer
52 Melanoma Kim Margolin, Brian O'Sullivanand Raphael Pollock

Central nervous system and ocular cancers
53 Central nervous system Caroline Chung, Do-Hyun Nam and Roger Stupp
54 Eye: Choroidal melanoma, retinoblastoma, ocular adnexal lymphoma and eyelid cancers Paul T. Finger Sarcoma
55 Bone (osteosarcoma) Elizabeth J. Davis, Geoffrey Siegel, Mary Feng, J. Sybil Biermann and Rashmi Chugh
56 Soft tissue Colleen Dickie, Abha Gupta, Raphael Pollock and Brian O'Sullivan Childhood malignancies
57 Paediatric tumours Hatel Moonat, Anna R. Franklin, Andrea Hayes-Jordan, Mary F. McAleer and Winston W. Huh

Specific cancer situations
58 Cancer of unknown primary (non-head and neck) George Pentheroudakis and Nicholas Pavlidis
59 HIV and transplant-related neoplasms
59.1 HIV-related neoplasms Jean-Philippe Spano, Dominique Costagliola, Sylvain Choquet, Fabrice Bonnet, Armelle Lavolle and Laurent Quero
59.2 Post-transplantation lymphoproliferative disease Jean-Philippe Spano, Sylvain Choquet, Fabrice Bonnet, Armelle Lavolle and Laurent Quero
59.3 Cancer after solid organ transplantation Jerome Martin Laurence

Index