Movement Disorders in Clinical Practice

K Ray Chaudhuri is Consultant Neurologist and Professor of Neurology and Movement Disorders at King’s College Hospital NHS foundation Trust, University Hospital Lewisham, King’s College London and the Institute of Psychiatry. William G Ondo is Professor of Neurology at Baylor College of Medicine, and Associate Director at the Parkinson’s Disease Center and Movement Disorders Clinic in Houston, Texas.

Contents.- 1. Parkinson’s disease - Introduction - Epidemiology, incidence, and prevalence - Risk factors - Genetic factors - Pathophysiology - Symptoms and signs - Confirmation of diagnosis - Management of Parkinson’s disease - Neuroprotection - Stereotactic thalamotomy and deep brain stimulation - Transplant therapies - Nondopaminergic drug therapy - Specialist nursing care - Cost of care - Mortality and prognosis - Conclusions.- 2. Parkinsonian syndromes - Introduction - Neurodegeneration-linked parkinsonism - Multiple system atrophy - Progressive supranuclear palsy - Dementia with Lewy bodies - Corticobasal degeneration - Vascular pseudoparkinsonism - Other parkinsonian syndromes - Management - Conclusions.- 3. Dystonia - Definition - Classification - Location - Pathophysiology - Epidemiology - Genetics - Signs and symptoms - History and investigations - Treatments - Conclusions.- 4. Essential tremor - Introduction - Tremor subtypes and differential diagnosis - Physical examination and clinical evaluation - Epidemiology and neuropathology - Treatment.- 5. Restless legs syndrome -Restless legs syndrome - Periodic limb movements of sleep - RLS in children - Diagnostic evaluation - Epidemiology - Genetics - Pathophysiology - Treatment.- 6. Other movement disorders - Drug-induced movement disorders - Tics and Tourette’s syndrome - Chorea, ballismus and athetosis - Myoclonus - Ataxia - conclusions.