Complex Systems and Computational Biology Approaches to Acute Inflammation

Dr. Yoram Vodovotz is currently a Professor of Surgery, Immunology, Computational and Systems Biology, Bioengineering, Clinical and Translational Science, and Communication Science and Disorders at the University of Pittsburgh School of Medicine. His research focus is the systems biology of inflammation. He is the Director of the Center for Inflammation and Regeneration Modeling at the McGowan Institute for Regenerative Medicine, a co-founder and past President of the Society for Complex Acute Illness, and a co-founder of Immunetrics, Inc., a Pittsburgh-based company that is commercializing this mathematical modeling work. He has published over 300 manuscripts, including three books. Dr. Gary An is a Professor of Surgery and Vice-Chairman for Surgical Research in the Department of Surgery at the University of Vermont Larner College of Medicine. He is a founding member of the Society of Complexity in Acute Illness and past president of the Swarm Development Group, one of the original organizations promoting the use of agent-based modeling for scientific investigation. In addition to being an active trauma/critical care surgeon he has worked on the application of complex systems analysis to sepsis and inflammation since 1999 and consists of development of mechanism-based computer simulations and integration of machine learning and artificial intelligence with multi-scale simulation models for discovery of therapeutic control modalities.

Part I: OverviewChapter 1:  "An Overview of the Translational Dilemma and the Need for Model-based Precision Medicine" Yoram Vodovotz and Gary An
Part II:  "Computational Modeling Methods and Biomedical Applications"Chapter 2: Translational Equation-based Modeling -Gilles ClermontChapter 3:  Agent-based Modeling in Translational Systems Biology -Gary An Chapter 4: Integrating Data-driven and Mechanistic Modeling in Sepsis and Trauma -Yoram VodovotzChapter 5: Therapeutics as Control:Model-based approaches for control discovery -Chase Cockrell, Judy Day, Gary An
Part III: Translational Modeling of Sepsis and TraumaChapter 6: Disorder of Systemic Inflammation in Sepsis and Trauma: A Systems Perspective -Tim Billiar Chapter 7: Multiscale Equation-based Models: Insights for Inflammation and Physiological Variability -Ioannis AndroulakisChapter 8: In silicoTrials and Personalized Therapy for Sepsis and Trauma -Vodovotz, Bartels and AnChapter 9: Computational Modeling of the Coagulation Response -Scott Diamond
Part IV: Translational Modeling of Organ/Tissue Specific Inflammatory Disease Processes Chapter 10: Disorder of Localized Inflammation in Wound Healing -Stephen BadylakChapter11: Equation-based Models of Wound Healing and Collective Cell Migration -Julia Arciero and David SwigonChapter 12: Agent-based Models of Wound Healing -Yoram Vodovotz and Gary AnChapter 13: Tissue realistic translational modeling of gut inflammation -Chase Cockrell and Gary AnChapter 14: Data-DrivenModeling of Liver Injury, Inflammation, and Fibrosis -Ruben Zamora and Yoram VodovotzChapter 15: Computational Modeling of Tuberculosis -Denise Kirschner
Part V: Future Perspectives: Translation to ImplementationChapter 16:  "The Rationale and Implementation of Model-based Precision Medicine for Inflammatory Diseases"Gary An and Yoram Vodovotz