Complex Systems and Computational Biology Approaches to Acute Inflammation

An overview of the Translational Dilemma and the need for Translational Systems Biology of inflammation.- Part I: Complex Systems Methods and Applications.- Translational Equation-based Modeling.- Agent-based Modeling in Translational Systems Biology.- Analysis of Heart Rate Variability.- Analysis of Ventilatory Pattern Variability.- Part II: Translational Modeling of Sepsis and Trauma.- Disorder of Systemic Inflammation in Sepsis and Trauma: A Systems Perspective.- Multi-scale equation-based models: Insights for Inflammation and Physiological Variability.- Integrating Data Driven and Mechanistic Models of the Inflammatory Response in Sepsis and Trauma.- In silico Trials and Personalized Therapy for Sepsis and Trauma.- Part III: Translational Modeling of Wound Healing.- Disorder of Localized Inflammation in Wound Healing: A Systems Perspective.- Equation-based Models of Wound Healing and Collective Cell Migration.- Agent-based Models of Wound Healing.- Part IV: Translational Modeling of Host-pathogen Interactions.- Modeling Host-Pathogen Interactions in Necrotizing Enterocolitis.- Modeling Host-Vector-Pathogen Immuno-inflammatory Interactions in Malaria.- Part V: Future Perspectives.- Translation to Implementation.- The Rationale and Implementation of Translational Systems Biology as a new Paradigm for the Study of Inflammation.- Index.