Computational Strategies Towards Improved Protein Function Prophecy of Xylanases from Thermomyces lanuginosus

Buch | Softcover
44 Seiten
2012 | 2012 ed.
Springer-Verlag New York Inc.
978-1-4614-4722-1 (ISBN)

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Computational Strategies Towards Improved Protein Function Prophecy of Xylanases from Thermomyces lanuginosus - MVK Karthik, Pratyoosh Shukla
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This Brief reports on the interplay of an amino-acid mutation towards substrate which could lead to enhanced effects on mutant. There are very few reports showing such stable, energy efficient model towards improved protein function prediction screening in-silico structure based mutagenesis of xylanases from Thermomyces lanuginosus​
This Brief reports on the interplay of an amino-acid mutation towards substrate which could lead to enhanced effects on mutant. These effects need  to  be given consideration in  the  engineering  processes of protein stability and further exploration of such learning are required to provide novel indication for selection of an enzymes.  There  are  very  few  reports  showing  such  stable,  energy  efficient  model  towards  improved  protein function prediction screening in-silico structure based mutagenesis of xylanases from Thermomyces lanuginosus​

Introduction.- Material and Methods.- Selection of sequences, 3D structures and multiple sequence alignment.-  Mutant generation.- Energy minimization.- Stereo-chemical quality check and analysis of non-bonded interactions.- Protein-protein docking.- InterProScan.- Identification of functionally important regions of wild type viz. Endo-1, 4-beta xylanases (1YNA).- 3d2GO server: From protein 3D structure to Gene Ontology (GO) term.-   Results and discussions.- Conclusion.

Reihe/Serie SpringerBriefs in Systems Biology
Zusatzinfo 12 Illustrations, color; VII, 44 p. 12 illus. in color.
Verlagsort New York, NY
Sprache englisch
Maße 155 x 235 mm
Themenwelt Informatik Weitere Themen Bioinformatik
Naturwissenschaften Biologie Biochemie
Naturwissenschaften Biologie Genetik / Molekularbiologie
ISBN-10 1-4614-4722-4 / 1461447224
ISBN-13 978-1-4614-4722-1 / 9781461447221
Zustand Neuware
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