Thymus Gland Pathology (eBook)

Clinical, Diagnostic and Therapeutic Features
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2009 | 2008
XVIII, 274 Seiten
Springer Milan (Verlag)
978-88-470-0828-1 (ISBN)

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The thymus is a gland that over the last two centuries has generated great awareness not only from the anatomical perspective but also for the physiological and pat- logical roles it plays in many disease processes. Prior to the early studies on its th anatomy and physiology in the 18 century, the thymus was believed to perform - usual and curious functions such as purification of the nervous system, providing a protective cushion for the vasculature of the superior mediastinum, fetal nouri- ment, or more spiritual roles such as being the seat of the soul, among others. D- th ing the 19 century important anatomical/physiological studies took place focusing on the role of the thymus in pathological conditions. However, it was not until the th middle of the 19 century that a more comprehensive analysis of the role of the thymic gland and its role in pathogenesis began to emerge. Currently, while the knowledge gained on the diverse aspects of the thymic gland has furthered our understanding of its role in a gamut of processes, more knowledge is still being sought, and by no means is a full understanding of the gland's physi- ogy and pathology complete. Different aspects, including its purported endocrine function, its association with other autoimmune diseases like multiple sclerosis, rheumatoid arthritis, and lupus erythematosus, among others, are under evaluation and research.
The thymus is a gland that over the last two centuries has generated great awareness not only from the anatomical perspective but also for the physiological and pat- logical roles it plays in many disease processes. Prior to the early studies on its th anatomy and physiology in the 18 century, the thymus was believed to perform - usual and curious functions such as purification of the nervous system, providing a protective cushion for the vasculature of the superior mediastinum, fetal nouri- ment, or more spiritual roles such as being the seat of the soul, among others. D- th ing the 19 century important anatomical/physiological studies took place focusing on the role of the thymus in pathological conditions. However, it was not until the th middle of the 19 century that a more comprehensive analysis of the role of the thymic gland and its role in pathogenesis began to emerge. Currently, while the knowledge gained on the diverse aspects of the thymic gland has furthered our understanding of its role in a gamut of processes, more knowledge is still being sought, and by no means is a full understanding of the gland's physi- ogy and pathology complete. Different aspects, including its purported endocrine function, its association with other autoimmune diseases like multiple sclerosis, rheumatoid arthritis, and lupus erythematosus, among others, are under evaluation and research.

Preface 6
Contents 8
Contributors 11
The Thymus from Antiquity to the Present Day: the History of a Mysterious Gland 16
Embryology and Anatomy of the Thymus Gland 28
Physiology and Immunology of the Thymus Gland 34
Congenital Pathology of the Thymus 46
Hyperplastic and Inflammatory Pathology of the Thymus 53
Benign and Malignant Tumors 68
Clinical Features of Thymus Pathology 81
Thymus and Myasthenia Gravis. Pathophysiological and Clinical Features 100
Radiologic Diagnosis: X- ray, CT and MRI 110
PET Features 121
Minimally Invasive and Surgical Diagnosis 131
Surgical Anatomy of the Thymus Gland 143
Anesthesiological Problems in Thymus Gland Surgery 147
Conventional Techniques: Cervicotomy 158
Conventional Techniques: Median Sternotomy 165
Conventional Techniques: Transthoracic Approach 169
Open Videoassisted Techniques: Transcervical Approach 175
Open Videoassisted Techniques: Subxiphoid Approach with Bilateral Thoracoscopy 180
Open Videoassisted Techniques: Transcervical- Subxiphoid- Videothoraco-scopic Maximal Thymectomy 187
Open Videoassisted Techniques: Thoracoscopic Extended Thymectomy with Bilateral Approach and Anterior Chest Wall Lifting 193
Totally Endoscopic Techniques: Left- Sided Thoracoscopic Thymectomy 198
Totally Endoscopic Techniques: Right- Sided Thoracoscopic Thymectomy 205
Robotic Techniques 211
Complex Surgical Interventions in Superior Vena Cava Syndrome 216
Reinterventions for Thymoma Recurrences 220
Chemotherapy in Thymic Neoplasms 228
Radiotherapy in Thymic Neoplasms 232
Complementary Treatments in Thymic Neoplasms: Steroids and Octreotide 243
Thymus-related Myasthenia Gravis. Multimodal Therapy and Follow- up 249
Thymus Transplantation 257
Subject Index 270

Erscheint lt. Verlag 8.5.2009
Zusatzinfo XVIII, 274 p.
Verlagsort Milano
Sprache englisch
Themenwelt Medizin / Pharmazie Gesundheitsfachberufe
Medizinische Fachgebiete Chirurgie Herz- / Thorax- / Gefäßchirurgie
Medizin / Pharmazie Medizinische Fachgebiete Neurologie
Medizin / Pharmazie Medizinische Fachgebiete Onkologie
Medizin / Pharmazie Medizinische Fachgebiete Pädiatrie
Studium 2. Studienabschnitt (Klinik) Pathologie
Schlagworte classification • Computed tomography (CT) • CT • Endoscopy • Multidisciplinar Approach • Myasthenia gravis • Nuclear Magnetic Resonance (NMR) • Pathology • PET • positron emission tomography (PET) • radiotherapy • Staging • Steroids • Surgery • Thoracic Surgery • Thymectomy • Thymus • Thymus Gland • Thymus Transplantation • Transplantation • Tumor
ISBN-10 88-470-0828-X / 884700828X
ISBN-13 978-88-470-0828-1 / 9788847008281
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