Clinical Laboratory Animal Medicine

An Introduction
Buch | Softcover
504 Seiten | Ausstattung: Softcover & Online-Materialien
2019 | 5. Auflage
Wiley-Blackwell (Verlag)
978-1-119-48956-6 (ISBN)
78,11 inkl. MwSt
The revised fifth edition of »Clinical Laboratory Animal Medicine: An Introduction« is an accessible guide to basic information for conducting animal research safely and responsibly. It includes a review of the unique anatomic and physiologic characteristics of laboratory animals, husbandry practices, and veterinary care of many animals frequently used in research, including rodents, rabbits, ferrets, zebrafish, nonhuman primates, and agricultural animals.

The updated fifth edition adds two new chapters on zebrafish and large animals, new information on transgenic models and genetic editing, and expanded coverage of environmental enrichment and pain management. The book presents helpful tip boxes, images, and review questions to aid in comprehension and learning, and a companion website provides editable review questions and answers, instructional PowerPoints, and additional images not found in the book.

This important text:
  • Provides a complete introduction to laboratory animal husbandry, diseases, and treatments
  • Offers a user-friendly format with helpful content that highlights important concepts
  • Contains new knowledge relating to technical methodologies, diseases, drug dosages, laws and regulations, and organizations
  • Covers information on regulations, facilities, equipment, housing, and research variables as well as veterinary care
  • Includes new chapters on zebrafish and cattle, sheep, goats, and pigs

Written for veterinary technicians, veterinary students, practicing veterinarians, and research scientists, the fifth edition of »Clinical Laboratory Animal Medicine« continues to offer an essential guide to the ethical treatment and anatomic and physiological characteristics of research animals.

Lesley A. Colby, DVM, MS, DACLAM, is an Associate Professor and Senior Director of Animal Resources and Operations in the Department of Comparative Medicine at the University of Washington in Seattle, Washington, USA.

Megan H. Nowland, DVM, DACLAM, is an Associate Professor in the Unit for Laboratory Animal Medicine at the University of Michigan in Ann Arbor, Michigan, USA.

Lucy H. Kennedy, DVM, DACLAM, is an Assistant Professor in the Unit for Laboratory Animal Medicine at the University of Michigan in Ann Arbor, Michigan, USA.

About the Authors xii


Preface xiii


About the Companion Website xiv


1 Introduction to Laboratory Animal Medicine 1


Animals Used in Research, Teaching, and Testing 2


Ethical Considerations 8


Organizations 12


Bibliography 17


Further Reading 18


Chapter 1 Review 19


2 Regulations, Policies, and Principles Governing the Care and Use of Laboratory Animals 22


Animal Welfare Act and Regulations 22


Public Health Service Policy on Humane Care and Use of Laboratory Animals 28


Other Regulations, Policies, Guidance Documents, and Organizations 31


References 36


Further Reading 37


Chapter 2 Review 37


3 Facility Design, Housing, Equipment, and Management 39


Laboratory Animal Facility Design 39


Common Facility Classifications 46


Housing 50


Facility Equipment 59


Management 66


Bibliography 69


Further Reading 69


Chapter 3 Review 71


4 Mice 74


Genetics 74


Microbiologic Classifications 76


Uses 77


Behavior 77


Anatomic and Physiologic Features 78


Breeding and Reproduction 80


Husbandry 81


Techniques 86


Special Techniques: Transgenic Production Technology 96


Therapeutic Agents 101


Introduction to Diseases of Mice 101


Viral Diseases 107


References 114


Further Reading 119


Chapter 4 Review 122


5 Rats 124


Genetics 124


Microbiologic Classifications 125


Uses 126


Behavior 126


Anatomic and Physiologic Features 127


Breeding and Reproduction 129


Husbandry 130


Techniques 133


Therapeutic Agents 143


Introduction to Diseases of Rats 144


Bibliography 157


Further Reading 162


Chapter 5 Review 162


6 Gerbils 165


Uses 165


Behavior 166


Anatomic and Physiologic Features 166


Breeding and Reproduction 167


Husbandry 168


Techniques 170


Therapeutic Agents 176


Introduction to Diseases of Gerbils 176


Bibliography 181


Further Reading 183


Chapter 6 Review 184


7 Hamsters 185


Uses 185


Behavior 186


Anatomic and Physiologic Features 187


Breeding and Reproduction 189


Husbandry 190


Techniques 192


Therapeutic Agents 198


Introduction to Diseases of Hamsters 198


Bibliography 207


Further Reading 209


Chapter 7 Review 210


8 Guinea Pigs 212


Uses 212


Behavior 213


Anatomic and Physiologic Features 214


Breeding and Reproduction 216


Husbandry 218


Techniques 219


Therapeutic Agents 225


Introduction to Diseases of Guinea Pigs 226


Bibliography 238


Further Reading 240


Chapter 8 Review 242


9 Chinchillas 243


Uses 243


Behavior 244


Anatomic and Physiologic Features 244


Breeding and Reproduction 246


Husbandry 247


Techniques 249


Therapeutic Agents 253


Introduction to Diseases of Chinchillas 255


Bibliography 260


Further Reading 262


Chapter 9 Review 262


10 Zebrafish 264


Uses 264


Behavior 265


Anatomic and Physiologic Features 265


Reproduction and Life Stages 266


Husbandry 268


Techniques 274


Therapeutic Agents 278


Introduction to Diseases of Zebrafish 278


Bibliography 283


Further Reading 284


Chapter 10 Review 285


11 Rabbits 286


Breeds 286


Uses 287


Behavior 288


Anatomic and Physiologic Features 288


Breeding and Reproduction 291


Husbandry 293


Techniques 297


Therapeutic Agents 308


Introduction to Diseases of Rabbits 309


Bibliography 326


Further Reading 329


Chapter 11 Review 331


12 Ferrets 333


Uses 333


Behavior 334


Anatomic and Physiologic Features 334


Breeding and Reproduction 336


Husbandry 337


Techniques 339


Therapeutic Agents 347


Introduction to Diseases of Ferrets 347


Bibliography 365


Further Reading 369


Chapter 12 Review 369


13 Primates 371


Taxonomy 371


Uses 375


Behavior 376


Anatomic and Physiologic Features 377


Breeding and Reproduction 378


Husbandry 380


Techniques 383


Therapeutic Agents 390


Introduction to Diseases of Nonhuman Primates 390


Bibliography 410


Further Reading 413


Chapter 13 Review 416


14 Cattle, Sheep, Goats, and Pigs 417


Uses 417


Behavior 418


Anatomic and Physiologic Features 419


Breeding and Reproduction 419


Husbandry 420


Techniques 424


Therapeutic Agents 428


Introduction to Diseases of Agricultural Animals of Particular Importance to Research 428


Bibliography 434


Further Reading 435


Chapter 14 Review 435


15 Research Variables, Biosecurity, and Colony Health Surveillance 437


Research Variables 437


Biosecurity and Exclusion of Contaminants 445


Animal Colony Health Surveillance 448


Bibliography 455


Further Reading 455


Chapter 15 Review 456


Appendix 1: Normal Values 459


Appendix 2: Comparative Biologic and Reproductive Values by Species 464


Answers to Review Questions 467


Index 474

Erscheinungsdatum
Verlagsort Hoboken
Sprache englisch
Maße 181 x 253 mm
Gewicht 1056 g
Einbandart kartoniert
Themenwelt Veterinärmedizin Klinische Fächer Hämatologie
Veterinärmedizin Klinische Fächer Versuchstiere
Veterinärmedizin Kleintier
Weitere Fachgebiete Land- / Forstwirtschaft / Fischerei
Schlagworte Versuchstiere
ISBN-10 1-119-48956-3 / 1119489563
ISBN-13 978-1-119-48956-6 / 9781119489566
Zustand Neuware
Informationen gemäß Produktsicherheitsverordnung (GPSR)
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