Clinical Laboratory Animal Medicine

Karen Hrapkiewicz, DVM, MS, DACLAM, is a consultant in laboratory animal medicine and an adjunct faculty instructor at Henry Ford Community College in Dearborn, Michigan. Lesley Colby, DVM, MS, DACLAM is Senior Director of Animal Resources and Operations at the University of Washington in Seattle, Washington. Patricia Denison, LVT, LATG, is a licensed veterinary technician at Veterinary Emergency Service in Madison Heights, Michigan.

About the Authors xi Preface xiii About the Companion Web Site xv 1 Introduction to Laboratory Animal Medicine 1 Animals Used in Research, Product Safety Testing, and Education 2 Ethical Considerations 5 Organizations 9 References 14 Further Reading 14 Chapter 1 Review 15 2 Regulations, Policies, and Principles Governing the Care and Use of Laboratory Animals 18 Animal Welfare Act and Regulations 18 References 31 Further Reading 32 Chapter 2 Review 32 3 Facility Design, Equipment, Housing, and Management 34 Laboratory Animal Facility Design 34 Biosecurity 35 Facility Equipment 41 Housing 43 Management 48 References 50 Further Reading 50 Chapter 3 Review 51 4 Mice 54 Genetics 54 Microbiologic Classifications 56 Uses 57 Behavior 57 Anatomic and Physiologic Features 58 Breeding and Reproduction 60 Husbandry 61 Techniques 66 Special Techniques: Transgenic Production Technology 76 Therapeutic Agents 80 Introduction to Diseases of Mice 80 References 94 Further Reading 97 Chapter 4 Review 102 5 Rats 105 Genetics 105 Microbiologic Classifications 106 Uses 107 Behavior 107 Anatomic and Physiologic Features 108 Breeding and Reproduction 110 Husbandry 110 Techniques 113 Therapeutic Agents 123 Introduction to Diseases of Rats 123 References 138 Further Reading 140 Chapter 5 Review 143 6 Gerbils 145 Uses 145 Behavior 146 Anatomic and Physiologic Features 146 Breeding and Reproduction 147 Husbandry 148 Techniques 149 Therapeutic Agents 156 Introduction to Diseases of Gerbils 156 References 161 Further Reading 163 Chapter 6 Review 164 7 Hamsters 167 Uses 167 Behavior 168 Anatomic and Physiologic Features 169 Breeding and Reproduction 171 Husbandry 172 Techniques 173 Therapeutic Agents 179 Introduction to Diseases of Hamsters 182 References 189 Further Reading 190 Chapter 7 Review 192 8 Guinea Pigs 195 Uses 195 Behavior 196 Anatomic and Physiologic Features 197 Breeding and Reproduction 200 Husbandry 201 Techniques 202 Therapeutic Agents 208 Introduction to Diseases of Guinea Pigs 208 References 221 Further Reading 223 Chapter 8 Review 225 9 Chinchillas 227 Uses 227 Behavior 228 Anatomic and Physiologic Features 228 Breeding and Reproduction 230 Husbandry 231 Techniques 232 Therapeutic Agents 237 Introduction to Diseases of Chinchillas 239 References 244 Further Reading 245 Chapter 9 Review 246 10 Rabbits 249 Breeds 249 Uses 250 Behavior 251 Anatomic and Physiologic Features 251 Breeding and Reproduction 254 Husbandry 256 Techniques 259 Therapeutic Agents 271 Introduction to Diseases of Rabbits 271 References 289 Further Reading 292 Chapter 10 Review 295 11 Ferrets 298 Uses 298 Behavior 299 Anatomic and Physiologic Features 299 Breeding and Reproduction 301 Husbandry 302 Techniques 304 Therapeutic Agents 312 Introduction to Diseases of Ferrets 312 References 330 Further Reading 332 Chapter 11 Review 334 12 Primates 337 Taxonomy 337 Uses 341 Behavior 342 Anatomic and Physiologic Features 343 Breeding and Reproduction 344 Husbandry 345 Techniques 349 Therapeutic Agents 356 Introduction to Diseases of Nonhuman Primates 356 References 377 Further Reading 379 Chapter 12 Review 383 13 Research Variables and Quality Control 386 Research Variables: Intrinsic and Extrinsic Factors 386 Quality Control 395 Reference 400 Further Reading 400 Chapter 13 Review 401 Appendix 1: Normal Values 403 Appendix 2: Comparative Biologic and Reproductive Values by Species 408 Appendix 3: Supportive and Critical Care Products for Laboratory Animal Use 412 Answers to Review Questions 414 Index 417