Small Animal Therapeutics (eBook)

Front Cover 1
Small Animal Therapeutics 4
Copyright Page 5
Table of Contents 8
Preface 6
Chapter 1. General Principles of Drug Distribution and Dosage 12
Drug translocation 12
Factors affecting therapeutic response 13
Metabolism 20
Factors affecting dose frequency 23
Calculation of dose 27
Further reading 30
Chapter 2. Antibiotics 31
The properties of antibacterial drugs 31
Factors which influence the selection of an antibacterial agent 47
Treatment of some specific bacterial infections 54
Further reading 61
Chapter 3. Glucocorticoids 62
Glucocorticoid secretion 62
The mineralocorticoid actions 63
The glucocorticoid actions 65
The anti-inflammatory actions 66
Synthetic glucocorticoids 67
Uses of glucocorticoids 69
Complications of chronic glucocorticoid administration 74
Immunosuppressants other than glucocorticoids 76
Further reading 77
Chapter 4. Vaccination 78
The immune response 78
Inactivated vaccines 79
Live vaccines 79
Maternal antibody 81
Deleterious effects of vaccination 82
The vaccines 85
The vaccination regime 89
Further reading 90
Chapter 5. Analgesia 91
Pain physiology 91
Mechanisms of analgesics 93
Analgesic agents 94
General use of analgesic agents 99
Paracetamol poisoning 101
Further reading 101
Chapter 6. Tranquillizers, Sedatives, and General and Local Anaesthetics 102
Tranquillizers and sedatives 102
General anaesthetics 107
Local anaesthetics 119
Further reading 122
Chapter 7. Epilepsy 123
Stages of epilepsy 123
Classification of epileptic attacks 124
Aims of therapy 124
Antiepileptic drugs 125
Convulsions 129
Further reading 129
Chapter 8. Endoparasite Therapeutics 130
Therapeutic agents 130
Common endoparasite infections 134
Treatment of rare endoparasite infestations 138
Further reading 139
Chapter 9. Ectoparasite Therapeutics 140
Selective toxicity 140
Resistance 140
Therapeutic agents 143
Specific conditions 152
Further reading 156
Chapter 10. Fluid Therapy 157
Substances available for fluid replacement 157
Selection of fluid 160
Estimation of fluid requirements 162
ECG 163
Correction of fluid imbalance 166
Further reading 169
Chapter 11. The Gastrointestinal Tract 170
Vomiting 170
Drugs which affect intestinal movements 173
Constipation 176
Antidiarrhoeal drugs 178
Colitis 180
Hepatic/bile disorders 181
Pancreatic insufficiency 182
Malabsorption syndrome 184
Acute pancreatitis 185
Canine parvovirus infection 185
Feline infectious enteritis (panleucopenia) 185
Key-Gaskell syndrome (feline dysautonomia) 186
Flatulence 186
Further reading 186
Chapter 12. The Cardiovascular System 187
Diuretics 187
Agents used primarily to treat congestive heart failure 189
The treatment of progressive left-sided heart failure 196
Drugs for cardiac arrhythmias 197
Cardiac arrhythmias 201
Further reading 204
Chapter 13. The Respiratory Tract 205
Expectorants 205
Cough suppressants (antitussives) 207
Bronchial dilatation 208
Respiratory stimulants 210
Some respiratory conditions 211
Further reading 215
Chapter 14. The Reproductive System 216
Oestrous cycle in the dog 216
Oestrous cycle in the cat 217
Therapeutic control of the oestrous cycle 217
Misalliance 220
Induction of oestrus 221
Infertility in the dog 221
Infertility in the bitch 222
Reproductive disorders of the female 223
Reproductive disorders of the male 226
Further reading 228
Chapter 15. The Urinary Tract 229
Urinary incontinence 229
Urinary retention 231
Prostatitis (bacterial) 232
Cystitis/urinary tract infections 233
Canine urolithiasis 236
Kidney failure 240
Feline urolithiasis syndrome 244
Further reading 245
Chapter 16. The Endocrine System 246
The pituitary gland 246
The thyroid gland 249
The parathyroid gland 252
The pancreas 253
Further reading 260
Chapter 17. The Eye 261
Aqueous humour production and accommodation 261
The actions of some drugs used for therapeutics of the eye 262
Therapeutic aspects of some conditions of the eye 269
Further reading 275
Chapter 18. Cancer Chemotherapy 276
Chemotherapy is one approach 276
The cell cycle 276
Combination of agents 277
Chemotherapeutic agents 278
Antimetabolites 280
Antitumour antibiotics 281
Plant alkaloids 283
Some specific conditions 284
Mast cell tumours 284
Multiple myelomas 285
Mammary tumours 285
Further reading 285
Chapter 19. Vitamins and Minerals 286
Vitamin A 286
. vitamins 288
Vitamin C (ascorbic acid) 290
Vitamin D 291
Rickets 293
Vitamin . 294
Vitamin . 295
Essential fatty acids 296
Zinc 296
Type 2 297
Iron 297
Iron preparations 297
Further reading 298
Chapter 20. Poisons 299
General treatments 299
Insecticides 302
Herbicides 304
Rodenticides 305
Molluscicides 308
Miscellaneous organic compounds 309
Detergents and disinfectants 310
Paraffin oils 310
Bee stings 311
Wasp stings 311
Toad venom 311
Miscellaneous inorganic compounds 311
Aspirin 312
Benzoic acid 313
Ethylene glycol 313
Further reading 314
Chapter 21. The Law and Medicines 315
Medicines Act (1968) 315
Misuse of Drugs Act (1971) 323
Further reading 328
Index 330