Henipavirus -

Henipavirus

Ecology, Molecular Virology, and Pathogenesis

Benhur Lee, Paul A. Rota (Herausgeber)

Buch | Softcover
XII, 228 Seiten
2014 | 2012
Springer Berlin (Verlag)
978-3-642-44019-9 (ISBN)
192,59 inkl. MwSt

Henipaviruses form a new genus of emerging paramyxoviruses that are the deadliest human pathogens within the Paramyxoviridae family. This volume deals with the many facets of henipavirus biology, and covers our current understanding regarding the ecology, molecular virology, and pathogenesis of henipavirus infections. It is an international effort written by a multidisciplinary panel of experts at the front lines of research into this lethal emerging group of paramyxoviruses. The first section introduces the epidemiology and ecology of Nipah and Hendra viruses in their respective endemic areas, including a first-hand account of the discovery of Nipah virus during its initial outbreak in Malaysia; the next section documents the molecular virology of henipaviruses, and the substantial advances made towards understanding the unique features of henipavirus entry and tropism; and this is followed by accounts of the clinical and pathologic features of henipavirus infectionsin their human and naturally infected animal hosts. The next sections on pathogenesis provide a comprehensive reference on how henipaviruses counteract the innate immune system, and the relevant pathogenic features in animal challenge models developed to test potential therapeutic strategies. The final sections describe our current and future capabilities for diagnosis and control, including an account of potentially effective immunization strategies that are currently being tested.

This book will not only serve as a useful reference for the henipavirus field; it will be useful to basic and animal virologists, ecologists, epidemiologists, physicians, and others interested in emerging infectious viral diseases, as it showcases the multidisciplinary efforts required to understand the genesis, spread and hopefully, control, of a group of lethal emerging zoonotic pathogens.

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  • Introduction: Nipah virus : discovery and Origin.- Ecological aspects of Hendra virus.- Epidemiology of Henipavirus disease in humans.- Molecular Virology of the Henipaviruses.- Henipavirus receptor usage and tropism.- Henipavirus membrane fusion and viral entry.- Clinical and pathological manufestations of human Henipavirus infection.- Henipaviruses in their natural animal hosts.- Nipah and Hendra virus interactions with the innate immune system.- Animal challenge models of Henipavirus infection and pathogenesis.- Diagnosis of Henipavirus infection: current capabilities and future directions.- immunization strategies against Henipaviruses.- Subject Index
  • Erscheint lt. Verlag 15.10.2014
    Reihe/Serie Current Topics in Microbiology and Immunology
    Zusatzinfo XII, 228 p.
    Verlagsort Berlin
    Sprache englisch
    Maße 155 x 235 mm
    Gewicht 373 g
    Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Mikrobiologie / Infektologie / Reisemedizin
    Medizin / Pharmazie Medizinische Fachgebiete Pharmakologie / Pharmakotherapie
    Studium Querschnittsbereiche Infektiologie / Immunologie
    Naturwissenschaften Biologie Mikrobiologie / Immunologie
    Naturwissenschaften Biologie Ökologie / Naturschutz
    Weitere Fachgebiete Land- / Forstwirtschaft / Fischerei
    Schlagworte encephalitic illness • Fish and Wildlife Biology • Hendra virus • Nipah virus • respiratory illness • vaccines • zoonotic diseases
    ISBN-10 3-642-44019-3 / 3642440193
    ISBN-13 978-3-642-44019-9 / 9783642440199
    Zustand Neuware
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