Mouse in Biomedical Research -

Mouse in Biomedical Research (eBook)

Immunology
eBook Download: PDF
2006 | 2. Auflage
392 Seiten
Elsevier Science (Verlag)
978-0-08-046908-9 (ISBN)
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Immunology, the third volume in the four volume set, The Mouse in Biomedical Research, is a completely new addition to this series, dedicated to mouse immunology. It is based on the vast body of knowledge which has made the mouse the model of choice when studying immunity in man. Arguably more is known about the immune system in mice than any other species except man. In large part this is due to the power of genetic engineering to delineate molecular mechanisms. In this volume we present an Overview to mouse immunology, including both the innate and adaptive immune systems, followed by 15 chapters, each dealing with a specific area of immunology in the mouse. These chapters illustrate the power of genetic engineering in dissecting each component of the immune response from the development of lymphoid tissues to signal transduction pathways in activated cells.
Immunology, the third volume in the four volume set, The Mouse in Biomedical Research, is a completely new addition to this series, dedicated to mouse immunology. It is based on the vast body of knowledge which has made the mouse the model of choice when studying immunity in man. Arguably more is known about the immune system in mice than any other species except man. In large part this is due to the power of genetic engineering to delineate molecular mechanisms. In this volume we present an Overview to mouse immunology, including both the innate and adaptive immune systems, followed by 15 chapters, each dealing with a specific area of immunology in the mouse. These chapters illustrate the power of genetic engineering in dissecting each component of the immune response from the development of lymphoid tissues to signal transduction pathways in activated cells.

Front Cover 1
The Mouse in Biomedical Research: Immunology 4
Copyright Page 5
Table of Contents 6
List of Reviewers 11
List of Contributors 12
Foreword 14
Preface 16
Overview 18
Chapter 1. The Molecular Basis of Lymphoid Architecture in the Mouse 74
Chapter 2. The Biology of Toll-Like Receptors in Mice 126
Chapter 3. Genomic Organization of the Mouse Major Histocompatibility Complex 136
Chapter 4. Some Biological Features of Dendritic Cells in the Mouse 152
Chapter 5. Mouse Models Revealed the Mechanisms for Somatic Hypermutation and Class Switch Recombination of Immunoglobulin Genes 172
Chapter 6. Mouse Natural Killer Cells: Function and Activation 186
Chapter 7. Cytokine-Activated JAK-STAT Signaling in the Mouse Immune System 196
Chapter 8. Signal Transduction Events Regulating Integrin Function and T Cell Migration in the Mouse 212
Chapter 9. Mouse Models of Negative Selection 224
Chapter 10. Peripheral Tolerance of T Cells in the Mouse 240
Chapter 11. The Genetics of Mouse Models of Systemic Lupus 260
Chapter 12. Inhibitory Receptors and Autoimmunity in the Mouse 278
Chapter 13. Mouse Models of Immunodeficiency 292
Chapter 14. Mouse Models to Study the Pathogenesis of Allergic Asthma 308
Chapter 15. The Mouse Trap: How Well Do Mice Model Human Immunology? 320
Index 330
Colour Plates 392

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