Handbook of Laboratory Animal Science

Jann Hau, M.D., is Head of the Department of Experimental Medicine and the centralized Animal Care and Use Programme at the University of Copenhagen. He has had similar positions at the University of Uppsala and University of London (The Royal Veterinary College). Jann’s research has focused on the use of laboratory animals as models for humans in biomedical research and his expertise is in comparative medicine, reproductive physiology, immunology, and laboratory animal science and welfare Steven J. Schapiro, Ph.D., is an associate professor of comparative medicine in the Department of Comparative Medicine at the Michale E. Keeling Center for Comparative Medicine and Research of The University of Texas MD Anderson Cancer Center. Steve earned his PhD from the University of California at Davis in 1985 in Comparative Psychology, after receiving his BA in Behavioral Biology from Johns Hopkins University. He completed a postdoctoral research fellowship at the Caribbean Primate Research Center of the University of Puerto Rico.

Animal research ethics. Alternatives: refinement, reduction and replacement of animal uses in the life sciences. Laboratory animal genetics and genetic quality control. Experimental design and statistical analysis. Behavioral needs and management of laboratory animals. Welfare assessment and humane endpoints. Impact of the biotic and abiotic environment on animal experiments. Animal research facility design and equipment considerations for conventional, barrier, and containment housing systems. Genetically modified mice. Microbiological status. Laboratory animal nutrition in routine husbandry, and experimental and regulatory studies. Common nonsurgical techniques and procedures. Laboratory animal analgesia, anesthesia and euthanasia. Surgery: basic principles and procedures. Applications of implantable radio telemetry in small laboratory animals. Physiological, hematological, and clinical chemistry. Postmortem procedures animal models for diabetes: basic principles and management. Animal models of spinal cord injury. Animal models in pain research. Rodents, sheep and non-human primates as models for human pregnancy and fetal development. Animal models in biodefense research. Animal models in neuroscience. Animal models for psychological disorders. Animal models for human behavior. Animal models of cardiovascular disease. Animal models in pharmacology and toxicology. Animal models in mycology. Animal models in oral health sciences. Animal models of hearing loss, tinnitus, and hyperacusis. Animal models for otolaryngological disorders. Animal models for eye diseases. Animal models in aids research. Models of human cancer. An overview of global legislation, regulations and policies. Laboratory animal science and service organizations. Education and training. Assessment of animal care and use programs. Reduction and refinement applied to animal models