Bovine respiratory disease

Keith D. DeDonder graduated from Kansas State University College of Veterinary Medicine and spent several years in private practice before returning to pursue a PhD and complete a residency in clinical pharmacology at Kansas State University. The focus of this research was on antimicrobial resistance in bovine respiratory disease (BRD) and the effects of clinical BRD on the pharmacokinetics and pharmacodynamics of an antibiotic and its correlation to treatment outcome. Dr. DeDonder is now director of clinical services at the Veterinary and Biomedical Research Center in the United States providing quality research to the veterinary and biomedical community.

1. Bovine respiratory disease complex (BRDC)
Introduction and global importance
Types of disease
2. Aetiology
Common viral agents
Bovine diarrhoea virus (BVDV)
Bovine respiratory syncytial virus (BRSV)
Bovine herpes virus (BHV)
Parainfluenza virus-3 (PI3)
Bovine respiratory coronavirus (BRCV)
Common bacterial agents
Mannheimia haemolytica (MH)
Pasteurella multocida (PM)
Histophilus somni (HS)
Mycoplasma bovis (MB)
Other bacteria
3. Epidemiology
Disease spread
Management practices
4. Diagnosis
Clinical signs
Bacterial and viral diagnosis
Antemortem sampling
Postmortem sampling
5. Treatment
Antimicrobial therapy
Antimicrobial resistance (AR)
Ancillary therapy (AT)
6. Control
Vaccination
Bacterial vaccination
Viral vaccination
Management
Conclusions
References