Pathology of Laboratory Rodents and Rabbits

Stephen W. Barthold, DVM, MS, PhD, Dipl. ACVP, Hon. Member ACLAM, is Distinguished Professor Emeritus of Veterinary and Medical Pathology at the University of California, Davis, and former Director of the UC Davis Center for Comparative Medicine. He has over 40 years of experience in laboratory animal pathology.

Stephen M. Griffey, DVM, PhD, is Clinical Professor of Laboratory Animal Pathology and Director of the Comparative Pathology Laboratory at the UC Davis School of Veterinary Medicine. He has over 20 years of experience in laboratory animal pathology.

Dean H. Percy , DVM, MSc, PhD, Dipl. ACVP, is Professor Emeritus and former Chair of the Pathobiology Department, Ontario Veterinary College, Guelph, Ontario. He has over 50 years of experience in veterinary pathology and laboratory animal pathology.

Preface vii About the companion website ix 1 Mouse 1 Introduction, 1 Mouse Genetics and Genomics, 2 Nomenclature, 2 Common Inbred Strains, 3 Genomic Considerations for the Pathologist, 4 Anatomic Features, 5 Immunologic Idiosyncracies, 10 Bibliography for Introduction Through Anatomic Features, 11 General References on Diseases of Mice, 12 Infections of Laboratory Mice: Effects on Research, 12 Bibliography for Infections of Laboratory Mice: Effects on Research, 13 DNA Viral Infections, 14 RNA Viral Infections, 23 Retroelements and Retrovirus Infections, 38 Bibliography for Viral Infections, 44 Bacterial Infections, 50 Bibliography for Bacterial Infections, 72 Fungal Infections, 78 Bibliography for Fungal Infections, 81 Parasitic Diseases, 82 Bibliography for Parasitic Diseases, 88 Behavioral Disorders, 89 Bibliography for Behavioral Disorders, 91 Aging, Degenerative, and Miscellaneous Disorders, 91 Bibliography for Aging, Degenerative, and Miscellaneous Disorders, 106 Neoplasms, 108 Bibliography for Neoplasms, 117 2 Rat 119 Introduction, 119 Anatomic Features, 119 Bibliography for Behavioral and Anatomic Features, 121 General References on Diseases of Rats, 121 DNA Viral Infections, 121 RNA Viral Infections, 125 Bibliography for Viral Infections, 130 Bacterial Infections, 132 Fungal Infections, 145 Bibliography for Bacterial and Fungal Infections, 148 Parasitic Diseases, 151 Bibliography for Parasitic Diseases, 154 Age-Related Disorders, 154 Miscellaneous Disorders, 159 Environmental Disorders, 161 Drug-Related Disorders, 162 Bibliography for Age-, Miscellaneous-, Environmental and Drug-Related Disorders, 162 Neoplasms, 164 Bibliography for Neoplasms, 170 3 Hamster 173 Introduction, 173 Anatomic Features, 173 Bibliography for Introduction and Anatomic Features, 174 DNA Viral Infections, 175 RNA Viral Infections, 178 Bibliography for Viral Infections, 179 Bacterial and Fungal Infections, 180 Bibliography for Bacterial and Fungal Infections, 186 Parasitic Diseases, 188 Bibliography for Parasitic Diseases, 192 Nutritional and Metabolic Disorders, 193 Diseases Associated With Aging, 194 Environomental, Genetic, and Other Disorders, 196 Bibliography for Noninfectious Diseases, 197 Neoplasms, 197 Bibliography for Neoplasms, 198 4 Gerbil 199 Introduction, 199 Anatomic Features, 199 Bibliography for Anatomic Features, 200 Viral Infections, 200 Bibliography for Viral Infections, 201 Bacterial Infections, 201 Bibliography for Bacterial Infections, 204 Parasitic Diseases, 204 Bibliography for Parasitic Diseases, 205 Genetic, Metabolic, and Other Disorders, 206 Bibliography for Genetic, Metabolic, and Other Disorders, 209 Neoplasms, 209 Bibliography for Neoplasms, 211 5 Guinea Pig 213 Behavioral, Physiologic, and Anatomic Features, 213 Bibliography for Behavioral, Physiologic, and Anatomic Features, 217 Viral Infections, 218 Bibliography for Viral Infections, 221 Bacterial Infections, 222 Bibliography for Bacterial Infections, 231 Fungal Infections, 234 Bibliography for Fungal Infections, 235 Parasitic Diseases, 235 Bibliography for Parasitic Diseases, 239 Nutritional, Metabolic, and Toxic Disorders, 239 Bibliography for Nutritional, Metabolic, and Toxic Disorders, 244 Miscellaneous Other Disorders, 245 Bibliography for Miscellaneous Disorders, 249 Neoplasms, 250 Bibliography for Neoplasms, 252 6 Rabbit 253 Introduction, 253 Behavioral, Physiologic, and Anatomic Features, 253 Bibliography for Behavioral, Physiologic, and Anatomic Features, 257 DNA Viral Infections, 257 RNA Viral Infections, 264 Bibliography for Viral Infections, 269 Bacterial Infections, 271 Bibliography for Bacterial Infections, 288 Fungal Infections, 292 Bibliography for Fungal Infections, 296 Parasitic Diseases, 297 Bibliography for Parasitic Diseases, 304 Noninfectious Gastrointestinal Disorders, 306 Bibiliography for Noninfectious Gastrointestinal Disorders, 308 Aging and Miscellaneous Disorders, 308 Bibliography for Aging and Miscellaneous Disorders, 312 Nutritional, Metabolic and Toxic Disorders, 313 Bibliography for Nutritional, Metabolic, and Toxic Disorders, 316 Genetic Disorders, 318 Bibliography for Genetic Disorders, 319 Neoplasms, 320 Bibliography for Neoplasms, 323 Index 325