Chemical Carcinogenesis

Section I: Chemicals as Carcinogens.- Chemical Carcinogenesis by Polycyclic Aromatic Hydrocarbons.- N-Substituted Aromatic Compounds.- Metabolic Epoxidation of Aflatoxin B1 and Its Metabolites: Patterns of DNA Adduct Formation and Removal in Relation to Biological Effects.- The Problematic Use of Chemical Class Controls in Absence of Information on the Underlying Mechanism.- Discussion.- Section II: DNA Adducts.- DNA Lesions: Nature and Genesis.- DNA Alkaline Elution: Physical Basis of the Elution Process and Validation of this Method as a Screeing Procedure to Identify Chemical Carcinogens.- DNA Fragmentation: Its Predictivity as a Short Term Test.- Measurement of Viscous and Elastic Components of Native DNA Fiber Following Carcinogen Administration.- Initiation of Experimental Liver Carcinogenesis by Chemicals: Are the Carcinogen Altered Hepatocytes Stimulated to Grow into Foci by Different Selection Procedures Identical?.- Influence of DNA Conformation on DNA Methylation and the Direct Binding of N-Methyl-N-Nitroso-N1-Nitro-Guanidine.- Genotoxic Effects of Drugs: Experimental Findings Concerning Some Chemical Families of Therapeutic Relevance.- Discussion.- Section III: Chemicals as Promotors.- Phenobarbital and Other Liver Tumor Promotors.- Molecular Mechanisms of Multistage Carcinogenesis.- Alterations of Liver Architecture in Mice Treated with Anabolic Androgens and Diethylnitrosamine.- Discussion.- Section IV: Carcinogenesis as Multistep Process.- Some Critical Consideration Concerning the Sequential Analysis of Carcinogenesis with Chemicals.- Benign and Malignant Tumor Induction in Mouse Skin.- Progress in the Study of In Vitro Neoplastic Transformation.- Pulse-Carcinogenesis by Ethylnitrosourea in the Developing Rat Nervous System: Molecular and Cellular Mechanisms.- Chromatin, Nuclei and Water: Alterations and Mechanisms for Chemically-Induced Carcinogenesic.- The Cytoskeleton: An Intermediate in the Expression of the Transformed Phenotype in Malignant Cells.- Discussion.- List of Participants.- Contributor Index.