Marek’s Disease

1. Historical review.- 1. Introduction.- 2. József Marek and the first description of Marek’s disease.- 3. Classical studies, 1920–1939.- 4. The middle period, 1940–1959.- 5. Events since 1960.- 2. Clinical disease and its economic impact.- 1. Introduction.- 2. Occurrence of infection and disease.- 3. The disease during production.- 4. The disease at slaughter.- 5. Economic loss from disease.- 6. Conclusions.- 3. Pathology.- 1. Introduction.- 2. Gross appearances.- 3. Histopathological and ultrastructural appearances.- 4. Lymphoma-derived cell lines.- 5. Transplantable lymphomas.- 6. Factors affecting pathogenesis.- 4. Characteristics of the virus.- 1. Introduction.- 2. Virus strains.- 3. Physical and chemical properties.- 4. Isolation and cultivation.- 5. Virus replication.- 6. Viral antigens.- 7. Concluding remarks.- 5. Molecular biology of the virus.- 1. Introduction.- 2. Viral deoxyribonucleic acid.- 3. Viral proteins.- 4. Replication.- 5. Oncogenesis.- 6. Concluding remarks.- 6. Laboratory diagnosis.- 1. Introduction.- 2. Diagnosis of a field outbreak.- 3. Diagnosis of infection.- 7. Immunity.- 1. Introduction.- 2. Expression of impunity.- 3. Immune responses to Marek’s disease-associated antigens.- 4. Contribution of immune responses to the expression of immunity.- 5. Immunosuppression.- 8. Principles of vaccination.- 1. Introduction.- 2. Types of vaccine.- 3. Responses to vaccination.- 4. Mechanisms of protection.- 5. Factors affecting vaccine efficacy.- 6. Investigation of vaccine failures.- 7. Comparative efficacy of vaccines.- 8. Strategies and perspectives.- 9. Production of vaccines.- 1. Introduction.- 2. Production methods.- 3. Conclusion.- 10. Quality control and standardization of vaccines.- 1. Introduction.- 2. Safety.- 3. Efficacy.- 4. Purity.-5. Standard preparations.- 6. Recommended tests.- 11. Genetic resistance.- 1. Significance and historical aspects of genetic resistance.- 2. Expression of resistance.- 3. Mechanism of genetic resistance.- 12. Spread of Marek’s disease.- 1. Introduction.- 2. Spread of infection.- 3. Flock infection.- 4. Factors affecting the incidence of Marek’s disease.- 13. Control of Marek’s disease by the poultry industry: practical considerations.- 1. Introduction.- 2. Control by hygiene.- 3. Breeding for resistance.- 4. Control by vaccination.