Comparative Pharmacokinetics (eBook)

Jim Riviere, DVM, PhD, DSc (hon), ATS, is the Burroughs Wellcome Fund Distinguished Professor of Pharmacology, Alumni Distinguished Graduate Professor, and Director of the Center for Chemical Toxicology Research and Pharmacokinetics at North Carolina State University, and Editor of the Journal of Veterinary Pharmacology and Therapeutics.

Coauthors.

Preface.

1 Introduction.

2 Principles of Drug Movement in the Body.

3 Quantitative Structure-Permeability Relationships
(Xin-Rui Xia).

4 Absorption.

5 Distribution (with Jennifer Buur).

6 Renal Elimination.

7 Hepatic Biotransformation and Biliary Excretion (Ronald
Baynes).

8 Compartmental Models.

9 Noncompartmental Models.

10 Nonlinear Models.

11 Physiological Models (Teresa Leavens).

12 Dosage Regimens.

13 Simultaneous Pharmacokinetic-Pharmacodynamic Modeling
(Pierre-Louis Toutain).

14 Study Design and Data Analysis. (Jason
Chittenden).

15 Bioequivalence Studies (Marilyn Martinez).

16 Population Pharmacokinetic Models (Jason
Chittenden).

17 Dosage Adjustments in Disease States (Jennifer
Davis).

18 Interspecies Extrapolations.

19 Tissue Residues and Withdrawal Times (Sharon
Mason).

Index.

"This book is helpful in understanding and designing
pharmacokinetic studies, illustrating basic concepts and noting the
species differences. . . The book does a good job of explaining a
concept and then expands with more specific examples. It provides a
good base for pharmacokinetic modeling and illustrates the pitfalls
with interspecies extrapolation." (Doody's, 21 October 2011)