A Guide to Practical Toxicology

ADAM WOOLLEY is Director and Consultant Toxicologist, ForthTox Limited, Linlithgow, UK. He received his M.Sc. in Biochemistry from London University, London, UK. Mr. Woolley is a Fellow of the Royal College of Pathologists, London, UK, where he is an examiner in toxicology and is also a board member and Diplomate of the American Board of Toxicology. He is an Honorary Consultant at the School of Pharmacy and Pharmaceutical Sciences at Manchester University, Manchester and is a member of the British Toxicology Society and US Society of Toxicology. With over thirty five years of experience, including eighteen years in contract research and nine years in the pharmaceutical industry, Mr. Woolley is an expert in pharmaceutical development, including proteins and gene therapy agents, agrochemicals, human and veterinary pharmaceuticals, and industrial chemicals. He has conducted numerous toxicity studies, reviewed reports, and data packages, and is the author of the First Edition of Informa Healthcare’s A Guide to Practical Toxicology: Evaluation, Prediction, and Risk.

Introduction to toxicology: the necessity of measurement. Normality: definition and maintenance. Determination of toxicity: basic principles. Determination of toxicity in vitro. Safety Pharmacology. Determination: general and reproductive toxicology. Determination: genotoxicity and carcinogenicity. Determination: irritation and sensitization. Determination: environmental toxicology and epidemiology. Interpretation. Prediction of hazard. Background to risk due to toxicity. Risk assessment in practice and setting exposure limits. Risk assessment and management in the workplace. Risk assessment: carcinogenicity; the environment; evolution and overview of risk assessment. Evaluation of specific groups of chemicals. The future of toxicity testing.