Complexities 1 (eBook)

Jean-Pierre Briffaut is Honorary Director of Studies at the Institut Mines-Télécom, France. A member of the Institut Fredrik Bull, he is in charge of a working group on the complexity of systems of systems.

Foreword: Sharing Complexity: An Acclaim for Complex Thinking ix
Philippe KOURILSKY

Preface xiii
Jean-Pierre BRIFFAUT

Chapter 1 The Complexity of Cybersecurity 1
Thierry BERTHIER and Thomas ANGLADE

1.1 Formal approach to the complexity of cybersecurity 1

1.2 Cybersecurity in real life: Advanced persistent threats, computer networks, defense teams and complex log data 27

1.3 User and entity behavior analysis as a way of reducing complexity 39

1.4 Conclusion and future work 47

1.5 References 48

Chapter 2 Complexity and Biology: When Historical Perspectives Intersect with Epistemological Analyses 51
Céline CHERICI

2.1 Complexity throughout the history of thoughs on living 53

2.2 The living: Between potentialities and actualizations 64

2.3 Reductionist biotechnologies? 73

2.4 References 82

Chapter 3 Two Complexities: Information and Structure Content 87
Jean-Paul DELAHAYE

3.1 The simple, the random and the structured: A triangle of concepts key to a complete understanding 87

3.2 Calculation, the key to the solution 88

3.3 Thought experiment 89

3.4 Mathematical definition 90

3.5 Random complexity and structural complexity 91

3.6 Recent progress 92

3.7 Less undecidability 93

3.8 Experimentation 94

3.9 Appendices 95

3.10 References 99

Chapter 4 Leveraging Complexity in Oncology-A Data Narrative 101
Xosé M FERNÁNDEZ

4.1 Large collaborative research initiatives-the Human Genome Project 104

4.2 Human cell atlas - unraveling complexity 105

4.3 From bench to bedside 107

4.4 The battle with cancer 109

4.5 Health economics - cost is another matter 112

4.6 From molecules to medicine 115

4.7 Artificial intelligence 117

4.8 The fourth paradigm 120

4.9 Modeling the complexity of cancer 121

4.10 References 124

Chapter 5 Complexity or Complexities of Information: The Dimensions of Complexity 129
Jacques PRINTZ

5.1 Introduction 129

5.2 A brief historical overview 130

5.3 The phenomenology of complexity in systems engineering 131

5.4 The four dimensions of complexity 138

5.5 The term "simplexity": A remark on Richard Feynman's Nobel lecture 142

5.6 Computational volume: Remarks on the first quantification of complexity 144

5.7 References 151

List of Authors 153

Index 155