Principles of Molecular Probe Design and Applications

Wellington Pham received a Ph.D. degree in Medicinal Chemistry from the University of Toledo. His postdoctoral training focused on PET chemistry at The Crump Institute for Molecular Imaging, UCLA Medical School, followed by two postdoctoral trainings in molecular imaging at the Center of Molecular Imaging Research and the Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School. Currently, he is Professor of Radiology at Vanderbilt University Medical Center and holds joint appointments in the Departments of Biomedical Engineering, Vanderbilt Ingram Cancer Center, and Vanderbilt Brain Institute. He served on several steering committees and conference organizers on molecular imaging and molecular probes and a recipient of the Distinguished Investigator Award of the Academy for Radiology & Biomedical Imaging Research (2019). His research interests include the discovery of biomarkers and imaging probes, combined with delivery technologies dedicated to cancer and Alzheimer’s disease, and he has published nearly 150 publications, including peer-reviewed articles, book chapters, conference abstracts/proceedings, editorials, and patents on these subjects. His research has been funded by NIH, DOD, VA grants, and ADEKA Corporation.   

Chapter 1: Overview of the fundamentals of chemistry for molecular probe design.- Chapter 2: Principles for the design of fluorescent dyes.- Chapter 3: Principles for the design of PET probes.- Chapter 4: Principles for the design of MRI probes.- Chapter 5: Solid-phase chemistry.- Chapter 6: Construction of molecular probes and imaging applications