Treating Autism with Bumetanide - Eric Lemonnier, Nouchine Hadjikhani, Yehezkel Ben-Ari

Treating Autism with Bumetanide

Buch | Hardcover
105 Seiten
2023 | Unabridged edition
Cambridge Scholars Publishing (Verlag)
978-1-5275-1890-2 (ISBN)
74,80 inkl. MwSt
In spite of its high incidence, extensive media coverage and major clinical burden to families, there is not a single approved European or American drug treatment of Autism Spectrum Disorders (ASDs). The dominant genetic and psychiatric approaches to treat ASDs have various limitations, suggesting that a novel global approach to understand and treat ASDs is warranted. Based on the authors’ converged expertise on brain development, ASD treatment and brain imaging, this book provides a fresh view of the disorder which is validated by experimental imaging and large clinical trials, culminating in the first large phase 3 final pediatric trial (on 400 children in EU countries and the US) using a repositioning of a drug used for decades to treat hypertension and edema. The convergence of experimental and clinical data on this disorder is unprecedented, confirming the potential of the drug to be the first pediatric treatment of ASDs.After explaining the mechanisms underlying ASDs, we describe specific cases of children who, after treatment, considerably improved their sociability and reduced their agitation. The book also discusses the skepticism that the authors met from the tenants of pure genetics and psychiatry, and why the abyssal poverty of information on developmental disorders has hampered progress in understanding and treating ASD.

Yehezkel Ben-Ari is a leading neurobiologist, with over 40 years of experience working on brain development and disorders, particularly autism spectrum disorders. He has published more than 500 papers in leading scientific journals, and received awards from the French Medical Research Institute and the European and USA Foundations of Epilepsy. He is also Doctor Honoris Causae of the University of Liège, Belgium. Eric Lemonnier is a pedo-psychiatrist with a master’s degree in neuroscience and habilitation. He has published 30 scientific articles and is a leader of autism spectrum disorder (ASD) treatments, notably in Britanny and Limoges, where directed Autism resource expert centers. He has treated thousands of children with ASD.Nouchine Hadjikhani is a neuroscientist, Professor of Radiology at Harvard Medical School (Boston), and Invited Professor at the Gilberg Neuropsychiatric Center (Sweden). She has also directed the Neuroscience Cognitive Center of the Brain Mind Institute, Switzerland. She has published over 70 papers and has been awarded the Leenards Prize for Scientific Research.

Erscheinungsdatum
Verlagsort Newcastle upon Tyne
Sprache englisch
Maße 148 x 212 mm
Themenwelt Studium 2. Studienabschnitt (Klinik) Humangenetik
Naturwissenschaften Biologie Humanbiologie
Naturwissenschaften Biologie Zoologie
Technik
ISBN-10 1-5275-1890-6 / 1527518906
ISBN-13 978-1-5275-1890-2 / 9781527518902
Zustand Neuware
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