Biomedical Applications and Toxicity of Nanomaterials (eBook)

This book covers the recent trends on the biological applications of nanomaterials, methods for their preparation, and techniques for their characterization. Further, the book examines the fundamentals of nanotoxicity, methods to assess the toxicity of engineered nanomaterials, approaches to reduce toxicity during synthesis. It also provides an overview of the state of the art in the application of Artificial intelligence-based methodologies for evaluation of toxicity of drugs and nanoparticles. The book further discusses nanocarrier design, routes of various nanoparticle administration, nano based drug delivery systems, and the toxicity challenges associated with each drug delivery method. It presents the latest advances in the interaction of nanoparticles with the cellular environment and assess nanotoxicity of these engineered nanoparticles. The book also explores the comparative and mechanistic genotoxicity assessment of the nanomaterials. This book is useful source of information for industrial practitioners, policy makers, and other professionals in the fields of toxicology, medicine, pharmacology, food, and drugs.

Dr. Mohanan is a Fellow of the National Academy of Science and Royal Society of Biologists, UK. He was a JSPS Postdoctoral Fellow at the University of Tsukuba, Japan in the field of Neurotoxicity. He joined Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST), Govt. of India in 1989. As a toxicologist, he has been intimately associated with all the medical devices/technologies developed at SCTIMST. Currently, he heads the Division of Toxicology. He is a Visiting Professor and Visiting Researcher at Toyo University, Japan, and a Certified Biological Safety Specialist. He received a lifetime achievement award from the Society of Toxicology India, for his outstanding contribution to the field of toxicology. Dr. Mohanan has been teaching toxicology to postgraduates and guiding research scholars. The development of Human-on-a-chip is a new mega project, apart from several other externally funded research projects. He has patented an ELISA kit for the measurement of pyrogenicity and has made significant contributions to the development of medical device regulations in India. He received a certificate of appreciation from the Hon. Minister of Science and Technology, Govt. of India for the contribution to India getting full adherent status on GLP from OECD. He has authored 262 publications and edited 5 books. Presently, He is the Secretary-General of Society of Toxicology, India.

Dr. Sudha Kappalli is a Professor in the Department of Zoology, School of Biological Science, Central University of Kerala. Her research Areas include, Crustacean Growth - Reproduction interaction and its endocrine regulation, biodiversity of parasitic isopods and copepods and host-parasite interaction. She has obtained PhD from University of Calicut in 1993.  She has 27 years of teaching experience at P.G level. Recipient of CAS-PIFI Visiting Scientist Fellowship (2015), CAS-TWAS Visiting Scholar Fellowship (2009 and 2011), Commonwealth Academic Staff Fellowship (2007), INSA Visiting Scientist Fellowship (2007) and IAS Summer Teacher Fellowship (2005) and University Post-Doctoral Fellowship (1994). She has completed four major research projects funded by International Foundation for Science (Stockholm, Sweden), BRNS, UGC, KSCSTE and SERB as Principal Investigator. She has currently PI of three research projects funded by KSCSTE, DST-RFBR and DST-JSPS and published 40 research papers in the peer reviewed journals and 6 papers in conference proceedings with one book chapter. Dr. Sudha serves as a member for several professional and academic bodies of universities and government agencies. In honour of excellence in teaching.  Dr. Sudha was chosen for Dr. P.K. Rajan Memorial Excellent Award (2012), Prof. Sivaprasad Memorial Award (2013) and St. Berchmans Award (2013) for Best College Teacher in Kerala.

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This book covers the recent trends on the biological applications of nanomaterials, methods for their preparation, and techniques for their characterization. Further, the book examines the fundamentals of nanotoxicity, methods to assess the toxicity of engineered nanomaterials, approaches to reduce toxicity during synthesis. It also provides an overview of the state of the art in the application of Artificial intelligence-based methodologies for evaluation of toxicity of drugs and nanoparticles. The book further discusses nanocarrier design, routes of various nanoparticle administration, nano based drug delivery systems, and the toxicity challenges associated with each drug delivery method. It presents the latest advances in the interaction of nanoparticles with the cellular environment and assess nanotoxicity of these engineered nanoparticles. The book also explores the comparative and mechanistic genotoxicity assessment of the nanomaterials. This book is useful source of informationfor industrial practitioners, policy makers, and other professionals in the fields of toxicology, medicine, pharmacology, food, and drugs.