Advanced Manufacturing Operations Technologies

Dr. Sam A. Hout is a chartered chemical engineer and certified in business management by the American Production and Inventory Control Society (APICS). He also is a member of the International Society of Pharmaceutical Engineers (ISPE) and specializes in process engineering and business process improvement. He received his education and training in the UK (Ph.D. in Chemical Engineering, University of Bath) and in the United States (MBA, University of California). Dr. Hout is currently VP, of technical operations at KC Pharmaceuticals, California. For the past 20 years in drug manufacturing, he held the position of Sr. Director of Engineering, project management, and technology process transfers at SIEGFRIED Pharmaceuticals. Previously, Dr. Hout held the Sr. Manager of Engineering position at TEVA Pharmaceuticals, parenteral medicines in Irvine, California. These specialty divisions produced specialty drugs for hospital institutional markets worldwide. Before assuming the position at Teva, Dr. Hout was Director of Operations at PHENOMENEX, the leading global company in HPLC (High-Performance Liquid Chromatography) for drug separation and analysis. During the past thirty years, Hout has helped to guide leading companies in technical positions such as J&J, Medtronic, and Fischer Scientific in developing and producing oral solid dosage, medical devices, and diagnostic standards that combat disease and promote healthier lives. In working with a global market, Hout travels frequently throughout the United States, Europe, and the Far East. Major accomplishments include designing and constructing various plants, introducing many new products, optimization of several bio and pharmaceutical operations. Hout has consulted in many chemical engineering-affiliated industries.

1. Instrumentation. 2. Chemical Plant - Engineering Materials. 3. Pressure Vessels. 4. Thermodynamics – Mass, Enthalpy, Entropy, Free Energy, Internal Energy in Closed and Open Systems. 5. Fluid Dynamics – Crystallization, Sedimentation, and Particle Dynamics. 6. Fluid Mechanics. 7. Heat Transmission – Natural Convection, Forced Convection, Single- and Two-Phase (Boiling) Flow Systems. 8. Transport Phenomena. 9. Chemical Reaction Engineering. 10. Fuel and Power. 11. Electrochemistry/Corrosion. 12. Unit Operations. 13. Process Dynamics. 14. Mathematics. 15. Numerical Methods – Computation. 16. Chemical Plant Design. 17. Experimentation. 18. Multi-Phase Flow. 19. Bio-Chemical Engineering. 20. Industrial Inks, Dyes, and Pigments. 21. Industrial Plastics. 22. Coating. 23. Industrial Adhesives. 24. Electronic Materials Processing. 25. Nuclear Power Plant - Reactor Heat Removal. 26. Pharmaceutical Manufacturing. Appendix I. Process Flow Diagram – Component Preparation, Compounding, Fill/Finish, and Packaging of Liquid Aseptic Operation. Appendix II. Master Validation Plan. Appendix III. Hand Calculations – System Architecture and Computations for Nuclear Reactor Heat Removal Systems Computer Program. Appendix IV. Chemical Reaction Fouling. Appendix V. Proposal for New Plant construction. Appendix VI. The Accident at Three Mile Island. Appendix VII. Water Hammer in Nuclear Power Plants. Appendix VIII. Selection and Design of Industrial Furnace Heaters. Appendix IX. Chemical Reaction Fouling in Unit Operations. Appendix X. Analysis of Single-Phase Flow in Power Plant Drain Systems. Appendix XI. Case Studies. Appendix XII. Heavy Metals Testing.