Discovery of Small-Molecule Modulators of Protein–RNA Interactions for Treating Cancer and COVID-19 - Wan Gi Byun

Discovery of Small-Molecule Modulators of Protein–RNA Interactions for Treating Cancer and COVID-19

(Autor)

Buch | Hardcover
128 Seiten
2022 | 1st ed. 2023
Springer Verlag, Singapore
978-981-19-7813-5 (ISBN)
181,89 inkl. MwSt
This book describes the development of novel protein–RNA-binding assays and their applications in a high-throughput manner for the identification of small-molecule modulators of protein–RNA interactions to treat cancer and COVID-19.



Modulating protein–RNA interactions with small molecules is expected to provide novel biological insights of the interrelation of diseases with the protein–RNA interactome. The modulations may also be exploited therapeutically. For these reasons, the development of a simple, reliable, and sensitive protein–RNA-binding assay is necessary for high-throughput screening to discover new effective chemical entities capable of acting on diverse protein–RNA interactions. This book discusses the discovery of small-molecule modulators targeting protein–RNA interactions that are potentially valuable to treat cancer and COVID-19 by constructing novel high-throughput screening methods. The results of this dissertation provide valuable insights into the regulation of protein–RNA interactions in chemical biology and drug development.

Wan Gi Byun received his B.S. degree in Department of Chemistry at Seoul National University, Korea in 2015. In the same year, he joined Prof. Seung Bum Park’s group in the Department of Chemistry at the Seoul National University and started to study chemical biology and drug discovery. His research during Ph.D. involved the development of high-throughput screening systems and identification of small-molecule modulators of protein–RNA interactions to overcome human diseases including cancer and COVID-19. After he got his Ph.D. degree in 2022, he is currently a post-doctoral researcher in Department of Chemistry, Seoul National University. His current research focus on the development of broadspectrum, pan-coronavirus antiviral drugs.

1. Introduction.- 2. Identification of Small-Molecule Inhibitors of Oncogenic Lin28–Let-7 Interaction.- 3. Discovery of Small-Molecule Modulators of Protein–RNA Interactions by Fluorescence Intensity-Based Binding Assay.- 4. Harnessing Stress Granule Formation by Small Molecules to Inhibit the Cellular Replication of SARS-CoV-2.- Appendix.

Erscheinungsdatum
Reihe/Serie Springer Theses
Zusatzinfo 57 Illustrations, color; 85 Illustrations, black and white; XXXII, 128 p. 142 illus., 57 illus. in color.
Verlagsort Singapore
Sprache englisch
Maße 155 x 235 mm
Themenwelt Naturwissenschaften Biologie Zellbiologie
Naturwissenschaften Chemie Technische Chemie
Naturwissenschaften Physik / Astronomie Angewandte Physik
Technik Umwelttechnik / Biotechnologie
ISBN-10 981-19-7813-1 / 9811978131
ISBN-13 978-981-19-7813-5 / 9789811978135
Zustand Neuware
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