A Pharmacology Primer
Academic Press Inc (Verlag)
978-0-323-99289-3 (ISBN)
With full color illustrations as well as new examples throughout, this book remains a top reference for all industry and academic scientists and students directly involved in drug discovery or pharmacologic research. New material includes a discussion of the determination of target engagement, including numerous new ways to demonstrate the physical interaction of molecules with drug targets and new drug candidates such a mRNA, gene therapy, antibodies and information on CRISPR and genomics.
Dr. Terry Kenakin is Professor of Pharmacology at the University of North Carolina School of Medicine. Prior to this, he spent 7 years in drug discovery at Burroughs-Wellcome. He then moved to GlaxoSmithKline for 25 years. Dr. Kenakin has written 11 books on Pharmacology, is the Editor in Chief of the Journal of Receptors and Signal Transduction, is on numerous Editorial Boards. He is the Editor-in-Chief of Comprehensive Pharmacology (Elsevier, 2022). He is the recipient of the 2008 Poulsson Medal for Pharmacology awarded by the Norwegian Society of Pharmacology for achievements in basic and clinical pharmacology and toxicology. He has also been awarded the 2011 Ariens Award from the Dutch Pharmacological Society and the 2014 Gaddum Memorial Award from the British Pharmacological Society, and the 2020 Goodman and Gilman Award in Receptor Pharmacology from ASPET.
1. What is Pharmacology?
2. How Different Tissues Process Drug Response
3. Drug–Receptor Theory
4. Pharmacological Assay Formats: Binding
5. Drug Targets and Drug-Target Molecules
6. Agonists: The Measurement of Affinity and Efficacy in Functional Assays
7. Orthosteric Drug Antagonism
8. Allosteric Modulation
9. The Optimal Design of Pharmacological Experiments
10. Pharmacokinetics
11. Safety Pharmacology
12. The Drug Discovery Process
13. Selected Pharmacological Methods
Erscheinungsdatum | 26.08.2022 |
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Verlagsort | Oxford |
Sprache | englisch |
Maße | 216 x 276 mm |
Gewicht | 1360 g |
Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie |
Medizin / Pharmazie ► Pharmazie | |
Technik | |
ISBN-10 | 0-323-99289-7 / 0323992897 |
ISBN-13 | 978-0-323-99289-3 / 9780323992893 |
Zustand | Neuware |
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