The Neurobiology of the Gilles De La Tourette Syndrome and Chronic Tics: Part A

Marc E. Lavoie, PhD is currently research professor of Psychiatry and Neuroscience at the University of Montréal, and since 2001 he is directing the Cognitive and Social Psychophysiology Laboratory, at the research center of the Institut Universitaire en Santé Mentale de Montréal (Canada). His research training was completed in the field of psychophysics (Université de Moncton, Canada), experimental neuropsychology (Université de Montréal, Canada), developmental psychology (Universiteit van Amsterdam, the Nederland) and in psychobiology (Université de Lille, France). He directs a clinical research program currently funded by the Canadian Institutes of Health Research that addresses crucial issues about the relationship between brain functions, behavior, and cognition in various neurodevelopmental and habit disorders, primarily in Tourette’s syndrome and behavior-focused repetitive behavior. Andrea E. Cavanna, MD, PhD, FRCP, FANPA, SFHEA, works as a clinician (Consultant in Behavioural Neurology at the Department of Neuropsychiatry, National Centre for Mental Health, Birmingham, UK) and as an academic (Honorary Professor in Neuropsychiatry at Aston University, Birmingham, UK). His medical training was completed in Italy (University of Turin and A. Avogadro University, Novara) and in the United Kingdom (University College London). Since 2008 he has been Lead Consultant for the specialist Tourette syndrome clinic. His research activity focuses on the behavioural aspects of neurological conditions. He coordinates training activities directed at the future generation of clinical scientists by running the Tourette syndrome module of the MSc in Clinical Neuropsychiatry at the University of Birmingham.

Preface Marc E. Lavoie and Andrea E. Cavanna

Section I: Introduction and clinical definition 1. Historical background of the Gilles de la Tourette syndrome Olivier Walusinski 2. The neurobiology of Gilles de la Tourette syndrome and chronic tics James F. Leckman 3. Tourette syndrome: Current nosology and guidelines Andrea E. Cavanna 4. Update and recent progress in the neurobiology of Tourette syndrome Natalia Szejko

Section II: Neuroimaging and pathophysiology 5. Recent advances in neuroimaging of Tourette syndrome Nicholas Cothros and Davide Martino 6. Mechanistic insight into the pathophysiological basis of Tourette syndrome Charlotte L. Rae and Hugo D. Critchley 7. Course of TS from a clinical and neuroimaging perspective Laura Bogut Andersen, Camilla Groth, Liselotte Skov and Nanette Mol Debes 8. Altered structural connectivity in Gilles de la Tourette syndrome Yulia Worbe 9. The neural correlates of tic inhibition Elia Abi-Jaoude and Paul Sandor

Section III: The structure and function of neural circuits: Data from neuroimaging and electrophysiology 10. Somatomotor cortical mapping in Tourette syndrome using neuro-navigated transcranial magnetic stimulation Caitlin M. Smith, Hilmar P. Sigurdsson, Katherine Dyke, Rosa Sanchez Panchuelo, Susan T. Francis, Georgina M. Jackson and Stephen R. Jackson 11. Control of actions and tics: A psychophysiological perspective Simon Morand-Beaulieu, Rebecca P. Jordan, Elinor Baldwin, Julia Zhong and Denis G. Sukhodolsky 12.Integrating psychophysiology into cognitive-behavioral treatment for the Gilles de la Tourette syndrome Marc E. Lavoie, Marie-Ange Perrault and Julie Leclerc 13. The functional neuroimaging of Tourette syndrome and obsessive-compulsive disorder Tracy Bhikram 14. Co-occurring ADHD symptoms and electrophysiological correlates of cognitive control in Tourette syndrome Elizabeth Shephard, Madeleine J Groom and Georgina M Jackson