High-Throughput Screening Assays in Toxicology

Cell-Based Assays to Identify ERR and ERR/PGC Modulators.- Mitochondrial Membrane Potential Assay.- Cell-Based hERG Inhibition Assay in a High-Throughput Format.- Identifying CAR Modulators Utilizing a Reporter Gene Assay.- Study Liver Cytochrome P450 3A4 Inhibition and Hepatotoxicity Using DMSO-Differentiated HuH-7 Cells.- Acetylcholinesterase Inhibition Assays for High-Throughput Screening.- Cell-Based Assays to Identify Modulators of Nrf2/ARE Pathway.- Cell-Based Imaging Assay for Detection of Phospholipdosis.- GFP-LC3 High-Content Assay for Screening Autophagy Modulators.- Generation of iPSC-Derived Brain Organoids for Drug Testing and Toxicological Evaluation.- Zebrafish Behavioral Assays in Toxicology.- High Throughput Screening Assay Profiling for Large Chemical Databases.- A Quantitative High Throughput Screening Data Analysis Pipeline for Activity Profiling.- CurveP Method for Rendering High Throughput Screening Dose-Response Data into Digital Fingerprints.- Accounting for Artifacts in High Throughput Toxicity Assays.- Automatic Quantitative Structure-Activity Relationship Modeling to Fill Data Gaps in High-Throughput Screening.- Use In Silico and In Vitro Methods to Screen Hepatotoxic Chemicals and CYP450 Enzyme Inhibitors.