Fused Pyrimidine-Based Drug Discovery - Raj Kumar

Fused Pyrimidine-Based Drug Discovery

(Autor)

Buch | Softcover
320 Seiten
2022
Elsevier Science Publishing Co Inc (Verlag)
978-0-12-824531-6 (ISBN)
218,20 inkl. MwSt
Fused Pyrimidine-Based Drug Discovery covers all categories of fused-pyrimidines along with pharmacological and in silico studies. It covers chemistry and biological activities, as well as the design of novel fused-pyrimidine scaffolds. N-Heterocyclic scaffolds are found in most known drug candidates and are of interest to medicinal and organic chemists to design, synthesize and evaluate their biological properties. A variety of fused-pyrimidine molecules have been synthesized and extracted from natural resources and are found to exhibit various biological activities such as antifolates, anticancer agents, analgesics, antimetabolites, CNS active agents, and many more.

This book focuses on nomenclature, structural chemistry, and chemical and physical properties, along with various approaches for their synthesis. It is ideal for researchers in organic chemistry, both in academic and industrial settings and for postgraduates in chemistry and medicinal chemistry.

Raj Kumar Ph.D. is a Professor of Organic Medicinal Chemistry at Central University of Punjab, Bathinda, India 151001. He obtained his Ph.D. in Medicinal Chemistry (2007) from NIPER, Mohali, India and completed his postdoctoral fellowship (2007-2008) at the University of Maryland Baltimore County (UMBC), Maryland where he coinvented a fused heterocycle RK-33 (Raj Kumar-33) molecule for the treatment of Lung Cancer. His research interests focus on the design and synthesis of novel fused heterocycles of biological importance.

1. Introduction
2. FDA Approved Fused Pyrimidine-Based Drugs
3. Five-Membered Ring Fused Pyrimidine-Based Derivatives (eg. purines) and Biological Properties
4. Six- Membered Ring Fused Pyrimidine-Based Derivatives (eg. Quinazolines, pteridines) and Biological Properties
5. Seven-Membered Ring Fused Pyrimidine-Based Derivatives and Biological Properties
6. Eight-Membered Fused Pyrimidine Derivatives (eg. azocine) and Biological Properties
7. Naturally occurring fused pyrimidine derivatives and Medicinal Attributes
8. Molecular Modeling Studies of Fused Pyrimidine Derivatives at various receptors

Erscheinungsdatum
Reihe/Serie Heterocyclic Drug Discovery
Sprache englisch
Maße 152 x 229 mm
Themenwelt Naturwissenschaften Chemie Organische Chemie
Technik
ISBN-10 0-12-824531-X / 012824531X
ISBN-13 978-0-12-824531-6 / 9780128245316
Zustand Neuware
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