The ADME Encyclopedia

Drug dissolution and drug release Mathematical models of drug dissolution and drug release Diffusion layer model Danckwert’s model Interfacial barrier model First order model Higuchi model Korsmeyer-Peppas model Hixson-Crowell model Baker-Lonsdale model Weibull model In vitro dissolution testing Modalities of dissolution tests Biorelevant dissolution media  

Drug absorption Free diffusion Facilitated diffusion Active transport Transcytosis pH partition theory pKa determination Factors impacting drug absorption  

Drug distribution Factors impacting drug distribution Real volume of distribution Apparent volume of distribution Drug binding to plasma proteins Drug displacement Non-linear binding to plasma proteins Drug binding to tissue components One-compartment pharmacokinetic model Two-compartment pharmacokinetic model Central nervous system bioavailability Blood-brain barrier log BB Kpuu  

Drug metabolism Functionalization reactions Synthetic reactions Cytochrome P450 Phase III reactions Factors impacting on drug metabolism Genetic variants. Polymorphism Age Gender Environmental factors: enzyme induction Precision medicine Pharmacogenomic DNA chips Microsomes  

 Drug excretion Biliary excretion Enterohepatic recycling Enterohepatic recycling and antibiotics Renal excretion Glomerular filtration Tubular reabsorption Tubular secretion Clearance Organ clearance  

Routes of administration Oral route Migrating motor complex Enteric coating tablets Food-drug interactions Gastric emptying Gastroretentive drug delivery systems Multiparticulate drug delivery systems Gut microbiota Lipinski rule of five Permeation enhancers Intestinal perfusion models Bucal and sublingual route Rectal route Intravenous route Intravenous bolus Intravenous infusion Technological considerations for intravenous administration Intramuscular administration Subcutaneous administration Specialized parenteral routes Pulmonary administration Nasal administration Transdermal administration Permeation enhancers  

Next generation drug delivery systems Nanocarriers Surface-to-volume ratio Surface chemistry Nanotoxicology Drug release from nanocarriers Passive targeting Smart systems / stimuli-responsive systems Active targeting Mononuclear phagocyte system Absorption and distribution of nanocarriers Elimination of nanocarriers PEGylationADME Viral vectors  

Pharmacogenomics Enzyme polymorphism Transporter polymorphism Pharmacogenomics and pediatrics  

Bioavailability and bioequivalence Bioavailability Systemic bioavailability Generic drugs Post-approval changes Bioequivalence Absolute bioavailability Mass balance studies Bioequivalence studies Reference and test products Biopharmaceutical Classification System Biowaivers BCS subclasses Dissolution testing Pharmacodynamic studies  

Biopharmaceutical drug products Absorption of protein drugs Distribution of protein drugs Elimination of protein drugs ADME properties of insulins ADME properties of heparins ADME properties of gene-based biopharmaceuticals  

Drug-drug and food-drug interactions Plasma protein binding DDI Membrane transport DDI Metabolism DDI FDI based on induction of gastrointestinal changes  

In vitro and in silico ADME predictions Polarized cell lines Caco-2 MDCK Solubility Dissolution testing QSPR/QSAR Expert rules Central Nervous System Multiparameter Optimization Dynamic transit models Sandwich-cultured hepatocytes Single-cell expression systems Membrane vesicles Molecular dynamics simulations  

Drug tansporters ABC transporters MDR1 MRPs BCRP Solute carriers Organic anion transporters Organic cation transporters Peptide transporters  

Non-linear pharmacokinetics Linear pharmacokinetics Positive deviations from linear behavior Negative deviations from linear behavior  

Time-dependent pharmacokinetics  

Pharmacometrics and physiologic models