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Metal Ions in Biological Systems

Volume 33: Probing of Nucleic Acids by Metal Ion Complexes of Small Molecules

Astrid Sigel, Helmut Sigel (Herausgeber)

Buch | Hardcover
728 Seiten
1996
Crc Press Inc (Verlag)
978-0-8247-9688-4 (ISBN)
399,95 inkl. MwSt
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"Volume 33 focuses on the vibrant research area of probing nucleic acids--the carriers of the genetic code--by metal ion complexes of small molecules providing an authoritative, timely account of this fascinating topic by over 50 distinguished experts."

Molecular modelling of transition metal adducts with nucleic acids and their constituents; zinc complexes as targeting agents for nucleic acids; metallocene interactions with DNA and DNA processing enzymes; evidences for a catalytic activity of the DNA double helix in the reactions between DNA, platinum (II) and intercalators; trans-diammineplatinum (II) - what makes it different from CIS-DDP? coordination chemistry of a neglected relative of cisplatin and its interaction with nucleic acids; metal ions in multiple-stranded DNA; DNA interactions with substitution-intert transition metal ion complexes; effect of metal ions on the fluorescence of dyes bound to DNA; photolytic covalent binding of metal complexes to DNA; electrochemically activated nucleic acid oxidation; electron transfer between metal complexes bound to DNA - is DNA a wire?; porphyrin and metalloporphyrin interactions with DNA; selective DNA cleavage by metalloporphyrin derivatives; synthetic metalloporphyrins as probes of protein-DNA interactions; targeting of nucleic acids by iron complexes; nucleic acid chemistry of the cuprous complexes of 1,10-phenanthroline and derivatives; specific DNA cleavage by manganese (III) complexes; nickel complexes as probes of guanine sites in nucleic acid folding; hydrolytic cleavage of RNA catalyzed by metal ion complexes; RNA recognition and cleavage by iron (III)-bleomycin; metallobleomycin-DNA interactions - structures and reactions related to bleomycin-induced DNA damage.

Erscheint lt. Verlag 29.2.1996
Reihe/Serie Metal Ions in Biological Systems
Verlagsort Bosa Roca
Sprache englisch
Maße 210 x 280 mm
Gewicht 1088 g
Themenwelt Medizinische Fachgebiete Innere Medizin Nephrologie
Naturwissenschaften Biologie Biochemie
Naturwissenschaften Biologie Genetik / Molekularbiologie
Naturwissenschaften Chemie Anorganische Chemie
Technik
ISBN-10 0-8247-9688-8 / 0824796888
ISBN-13 978-0-8247-9688-4 / 9780824796884
Zustand Neuware
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