Radiomics and Radiogenomics

Ruijiang Li, PhD, is an Assistant Professor and ABR-certified medical physicist in the Department of Radiation Oncology at Stanford University School of Medicine. He is also an affiliated faculty member of the Integrative Biomedical Imaging Informatics at Stanford (IBIIS), a departmental section within Radiology. He has a broad background and training in medical imaging, with specific expertise in quantitative image analysis and machine learning as well as their applications in radiology and radiation oncology. He has received many nationally recognized awards, including the NIH Pathway to Independence (K99/R00) Award, ASTRO Clinical/Basic Science Research Award, ASTRO Basic/Translational Science Award, etc. Dr. Lei Xing is the Jacob Haimson Professor of Medical Physics and Director of Medical Physics Division of Radiation Oncology Department at Stanford University. He also holds affiliate faculty positions in Department of Electrical engineering, Medical Informatics, Bio-X and Molecular Imaging Program at Stanford. Dr. Xing’s research has been focused on inverse treatment planning, tomographic image reconstruction, CT, optical and PET imaging instrumentations, image guided interventions, nanomedicine, imaging informatics and analysis, and applications of molecular imaging in radiation oncology. Dr. Xing is an author on more than 280 peer reviewed publications, a co-inventor on many issued and pending patents, and a co-investigator or principal investigator on numerous NIH, DOD, ACS and corporate grants. He is a fellow of AAPM (American Association of Physicists in Medicine) and AIMBE (American Institute for Medical and Biological Engineering). Dr. Sandy Napel is Professor of Radiology, and Professor of Medicine and Electrical Engineering (by courtesy) at Stanford University. His primary interests are in developing diagnostic and therapy-planning applications and strategies for the acquisition, visualization, and quantitation of multi-dimensional medical imaging data. He is the co-director of the Radiology 3D and Quantitative Imaging Lab, and co-Director of IBIIS (Integrative Biomedical Imaging Informatics at Stanford). Daniel L. Rubin, MD, MS, is Associate Professor of Radiology and Medicine (Biomedical Informatics Research) at Stanford University. He is Principal Investigator of two centers in the National Cancer Institute's Quantitative Imaging Network (QIN), Chair of the QIN Executive Committee, Chair of the Informatics Committee of the ECOG-ACRIN cooperative group, and past Chair of the RadLex Steering Committee of the Radiological Society of North America. His NIH-funded research program focuses on quantitative imaging and integrating imaging data with clinical and molecular data to discover imaging phenotypes that can predict the underlying biology, define disease subtypes, and personalize treatment. He is a Fellow of the American College of Medical Informatics and haspublished over 160 scientific publications in biomedical imaging informatics and radiology.

Part I: Introduction



1. Principles and rationale of radiomics and radiogenomics



Sandy Napel



Part II: Technical Basis



2. Imaging informatics: an overview



Assaf Hoogi, Daniel Rubin



3. Quantitative imaging using CT



Lin Lu, Lawrence H. Schwartz, Binsheng Zhao



4. Quantitative PET/CT for radiomics



Stephen R. Bowen, Paul E. Kinahan, George A. Sandison, Matthew J. Nyflot



5. Common techniques of quantitative MRI



David Hormuth II, Jack Virostko, Ashley Stokes, Adrienne Dula, Anna G. Sorace, Jennifer G. Whisenant, Jared Weis, C. Chad Quarles, Michael I. Miga, Thomas E. Yankeelov



6. Tumor segmentation



Spyridon Bakas, Rhea Chitalia, Despina Kontos, Yong Fan, Christos Davatzikos



7. Habitat imaging of tumor evolution by magnetic resonance imaging (MRI)



Bruna Victorasso Jardim-Perassi, Gary Martinez, Robert Gillies



8. Feature extraction and qualification



Lise Wei, Issam El Naqa



9. Predictive modeling, machine learning, and statistical issues



Panagiotis Korfiatis, Timothy L. Kline, Zeynettin Akkus, Kenneth Philbrick, Bradley J. Erikson



10. Radiogenomics: rationale and methods



Olivier Gevaert



11. Resources and datasets for radiomics



Ken Chang, Andrew Beers, James Brown, Jayashree Kalpathy-Cramer



Part III: Clinical Applications



12. Roles of radiomics and radiogenomics in clinical practice



Tianyue Niu, Xiaoli Sun, Pengfei Yang, Guohong Cao, Khin K. Tha, Hiroki Shirato, Kathleen Horst, Lei Xing



13. Brain cancer



William D. Dunn Jr, Rivka Colen



14. Breast cancer



Hui Li, Maryellen L. Giger



15. Lung cancer



Dong Di, Jie Tian, Shuo Wang



16. The essence of R in head and neck cancer



Hesham Elhalawani, Arvind Rao, Clifton D. Fuller



17. Gastrointestinal cancers



Zaiyi Liu



18. Radiomics in genitourinary cancers: prostate cancer



Satish Viswanath, Anant Madabhushi



19. Radiomics analysis for gynecologic cancers



Harini Veeraraghavan



20. Applications of imaging genomics beyond oncology



Xiaohui Yao, Jingwen Yan, Li Shen



Part IV: Future Outlook



21. Quantitative imaging to guide mechanism based modeling of cancer



David A. Hormouth II, Matthew T. McKenna, Thomas E. Yankeelov



22. Looking Ahead: Opportunities and Challenges in Radiomics and Radiogenomics