The Macrophage

The first volume in a group reviewing research into the innate or "natural" immune system. It covers the cell biology and host defence activity of the macrophage and includes discussions of the role that these cells play in haemopoiesis and the functioning of the nervous system.

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Historically, the study of immunology has focused to a large extent on the central role of antigen recognition and antibody structure and function in the response of the host to infection. In the last two decades, however, scientists have been turning their attention to the involvement of various cell types in host defence. Cells such as the macrophage, the natural killer cell, the neutrophil, and other humoral factors comprise this innate or "natural" immune system. They can take part in various immune responses without prior sensitization, and have important modulatory effects on later, specific responses. This volume provides a collection of reviews written by leading scientists. A broad range of topics is included relating to the molecular and cell biology of the macrophage, its host defence activity in human disease, and discussions of the important role that these cells play in haemopoiesis and the functioning of the nervous system. Advanced students and researchers in immunology, cell biology, and medicine should find "The Macrophage" to be a valuable source of current research into this field.