Absorption and Drug Development
Solubility, Permeability and Charge State
Seiten
2003
John Wiley & Sons Inc (Verlag)
978-0-471-42365-2 (ISBN)
John Wiley & Sons Inc (Verlag)
978-0-471-42365-2 (ISBN)
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Many times drugs work fine when tested outside the body, but when they are tested in the body they fail. One of the major reasons a drug fails is that it cannot be absorb by the body in a way to have the effect it was intended to have. Permeability, Solubility, Dissolution, and Charged State of Ionizable Molecules:* Helps drug discovery professionals to eliminate poorly absorbable molecules early in the drug discovery process, which can save drug companies millions of dollars.* Extensive tabulations, in appendix format, of properties and structures of about 200 standard drug molecules.
Alex Avdeef, PhD, is CEO and CSO of pION Inc., and has over thirty years of experience in chemical instrumentation and software development. He is an internationally know authority on solution chemistry and is the author of an extensive list of publications.
Preface. Acknowledgments. Definitions. 1. Introduction. 2. Transport Model. 3. Charge State. 4. Partitioning Into Octanol. 5. Partitioning Into Liposomes. 6. Solubility. 7. Permeability. 8. Summary and Some Simple Rules. References. Index.
Zusatzinfo | Illustrations |
---|---|
Verlagsort | New York |
Sprache | englisch |
Maße | 164 x 236 mm |
Gewicht | 592 g |
Einbandart | gebunden |
Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Laboratoriumsmedizin |
Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie | |
Naturwissenschaften ► Chemie | |
Technik | |
ISBN-10 | 0-471-42365-3 / 0471423653 |
ISBN-13 | 978-0-471-42365-2 / 9780471423652 |
Zustand | Neuware |
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