Recent Advancements in Biomarkers and Early Detection of Gastrointestinal Cancers (eBook)

This book describes various novel biomarkers for the early diagnosis of gastrointestinal (GI) cancers. It also highlights recent advances in understanding the role of molecular markers and biomarkers, such as volatile biomarkers, serum biomarkers, predictive and prognostic molecular markers for the early detection of GI cancers. Further, it discusses novel biomarkers, including circulating microRNAs, serum microRNA and plasma microRNA in GI cancer.

The book presents breakthrough technologies like ultra-sensitive nano-chips, nanosensors, nanodevices, biosensors, electrochemical biosensors, optical biosensors, DNA biosensors, synthetic biology devices, and 'omics' technologies for the early diagnosis of gastrointestinal cancer. In addition it examines the potential of genome-wide association studies, big data analytics, computation biology, systems biology, and nanotechnology for early diagnostics and therapeutics for gastrointestinal cancer, with a focus on personalized cancer treatment.

The book is a valuable source for researchers and clinicians engaged in detection and diagnosis of gastrointestinal cancers.

Dr. Pallaval Veera Bramhachari is currently Head of the Department of Biotechnology at Krishna University, India. He has served as a Postdoctoral Research Scientist at the Bacterial Pathogenesis Laboratory, Queensland Institute of Medical Research (QIMR), Australia, and DBT Postdoctoral Fellow at the Department of Microbiology and Cell Biology, Indian Institute of Science (IIsc), Bangalore. He holds a Ph.D. in Microbiology from Goa University, India. His major research focuses on applied microbiology and cell biology research, including biochemical mechanism of bacterial-biofilm formations, structure-function relationship of bacterial rhamnolipids, and basic and translational cancer research. He has published more than 115 research articles in leading peer-reviewed international journals, and 3 international books and has presented 47 abstracts at various national and international conferences. He has served as an editorial board member and reviewer for a number of national and international journals. He is a member of several international scientific societies and organizations, most importantly, Indian Science Congress & Society of Biological Chemists, India. He has received a number of various prestigious awards, notably, AP State Best Scientist Award 2017, DST SERB Young Scientist Award (2011) and nominated as an Associate Fellow of Andhra Pradesh Academy of Sciences (APAS) for the year 2016.

Dr. Neelapu Nageswara Rao Reddy is currently an Assistant Professor at the Department of Biochemistry and Bioinformatics, Institute of Science, Gandhi Institute of Technology and Management (GITAM) (deemed university), India. He obtained his Master's in Life Science from Pondicherry Central University, and Ph.D. in Evolutionary Bioinformatics from Andhra University, Visakhapatnam, India. His research interests include bioinformatics, cancer, and fungal biology with specialization in drug target discovery, HLA-based peptide vaccine design, genome analysis, phylogeny and evolution. Furthermore, he has expanded his research fields to understanding biochemical mechanisms of stress-induced proteins, structure-function relationship of proteins, and exploring next generation sequencing data to understand traits. He has been a recipient of several fellowships, like CSIR-UGC Junior Research Fellowship; and DAAD Visiting Fellowship, Germany. He has published more than 50 research articles in prestigious peer-reviewed international journals and presented 18 abstracts at various national and international conferences. He has served on the editorial board for a number of national and international journals, and is a member of several international scientific societies and organizations, most importantly, Indian Science Congress & Society of Biological Chemists, India.

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This book describes various novel biomarkers for the early diagnosis of gastrointestinal (GI) cancers. It also highlights recent advances in understanding the role of molecular markers and biomarkers, such as volatile biomarkers, serum biomarkers, predictive and prognostic molecular markers for the early detection of GI cancers. Further, it discusses novel biomarkers, including circulating microRNAs, serum microRNA and plasma microRNA in GI cancer. The book presents breakthrough technologies like ultra-sensitive nano-chips, nanosensors, nanodevices, biosensors, electrochemical biosensors, optical biosensors, DNA biosensors, synthetic biology devices, and 'omics' technologies for the early diagnosis of gastrointestinal cancer. In addition it examines the potential of genome-wide association studies, big data analytics, computation biology, systems biology, and nanotechnology for early diagnostics and therapeutics for gastrointestinal cancer, with a focus on personalized cancertreatment. The book is a valuable source for researchers and clinicians engaged in detection and diagnosis of gastrointestinal cancers.