Dynamic Hyperpolarized Nuclear Magnetic Resonance

Thomas Jue, Ph.D. Professor Department of Biochemistry and Molecular Medicine, University of California Davis He is an internationally recognized expert in developing and applying magnetic resonance techniques to study animal as well as human physiology in vivo and has published extensively in the field of magnetic resonance spectroscopy and imaging, near-infrared spectroscopy, bioenergetics, cardiovascular regulation, exercise, and marine biology. He served as a Chair of the Biophysics Graduate Group Program at UC Davis, where he started to redesign a graduate curriculum that balances physical science/mathematics formalism and biomedical perspective in order to promote interest at the interface of physical science, engineering, mathematics, biology, and medicine.The Handbook of Modern Biophysics represents an aspect of that effort. Dirk Mayer Dirk Mayer Associate Professor of Diagnostic Radiology and Nuclear Medicine at the University of Maryland and Director of Metabolic Imaging. He is a recognized expert on dynamic nuclear polarization (DNP) and MRI-based imaging techniques.He has optimized acquisition and reconstruction techniques, has constructed kinetic models for quantitative analysis, and has developed new biomolecular probes. His research focuses on using DNP to discover new approaches in tumor diagnosis and inmonitoring and assessing cardiovascular and liver pathologies, inflammatory diseases, and brain metabolism.

Principles of Dynamic Hypepolarized NMR.- The Design of a Hyperpolarizer.- Sample Preparation in Hyperpolarized NMR Experimentation.- Signal Sampling Strategies in Dynamic Hyperpolarized NMR.- Chemical Shift Imaging with Dynamic Hyperpolarized NMR.- Kinetic Modeling of Enzymatic Reactions in Analyzing Hyperpolarized NMR Data.- Using Hyperpolarized NMR to Understand  Biochemistry from Cells to Humans.- Innovating Metabolic Biomarkers for Hyperpolarized NMR.- New Insights on Metabolic Regulation from Dynamic Hyperpolarized NMR.- Novel Views on Heart Function from Dynamic Hyperpolarized NMR.- Dynamics of Substrate Selection in Muscle Metabolism.- Index.