Biopharmaceutics and Pharmacokinetics Considerations

Dr Rakesh K Tekade, Assistant Professor of the Department of Pharmaceutics, investigates the design, development and characterization of targeted nanotechnology based formulations for the site specific delivery of therapeutic drugs, siRNA, microRNA, plasmids, proteins and peptide for the treatment of cancer. His current research encompasses development of novel polymeric nanomaterial for effective cytosolic delivery of anticancer bioactives. Dr Tekade’s research is focused on designing a new generation of nanoparticles, which could identify the cancer cells and selectively deliver anticancer drugs and genes to inhibit the growth of cancer while sparing healthy tissues. His research work involves the applications of polymer chemistry, nanotechnology, molecular biology, pharmacokinetics/pharmacodynamics and imaging techniques. Dr Tekade has over 70 publications, 01 patent, 7 book chapters, and 3 editorial articles. He has delivered several invited research talks and presented research finding in more than 30 scientific conferences.

1. Routes of administrations and implication on drug bioavailability
2. Biopharmaceutics and Pharmacokinetics considerations in drug research
3. Bioavailability and bioequivalence research in Product Development
4. Pharmacokinetic characterization of drugs and new product designing
5. Pharmacokinetic Modulation with Particulate Drug Formulations
6. Dose, Dosage regimen and Dose adjustment
7. Implications of Bio-Nanotechnology in neuroscience, tissue engineering and cancer therapy
8. Physiologic pharmacokinetics models: Application and limitations
9. Chronopharmacokinetics in drug design
10. Drug toxicity and forensic pharmacokinetics
11. Recent advancements in Pharmacogenomics
12. Biocompatibility testing of biomaterials and biologicals
13. Metabolic kinetics
14. Animal handling and ethical considerations
15. Biopharmaceutic and pharmacokinetic aspects of controlled release systems
16. Degradation of biomaterials in biological environment
17. Safety and long-term toxicity evaluation of polymers used in Pharmaceutical Product Development: Regulatory considerations
18. Toxicity and toxicokinetic consideration in product development and drug research
19. Environmental and safety aspects of bio-nanotechnology
20. Toxicity considerations on repetitive accumulation of polymeric materials