Mechanical Support for Heart Failure

Jamshid H. Karimov, MD, PhD Adjunct Assistant Professor of Molecular Medicine Department of Biomedical Engineering Cleveland Clinic Lerner College of Medicine of Case Western Reserve University Lerner Research Institute Cleveland Clinic Kiyotaka Fukamachi, MD, PhD Professor of Molecular Medicine Department of Biomedical Engineering Cleveland Clinic Lerner College of Medicine of Case Western Reserve University Lerner Research Institute Cleveland Clinic Randall C Starling, MD, MPH, FACC, FAHA, FHFSA, FESC, FHFA Professor of Medicine Department of Cardiovascular Medicine Kaufman Center for Heart Failure Heart and Vascular Institute Cleveland Clinic

Part I. Overview of the Mechanical Circulatory Support (MCS).- 1. A History of Mechanical Circulatory Support.- 2. A Personalized History of Rotary Blood Pumps.- 3. Overview of Mechanical Circulatory Support Devices and Concepts.- 4. Physiology of Blood-pump Circulation in Heart Failure.- 5. Physiology of Blood Pump Circulation in Heart Failure.- 6. Engineering Requirements for Mechanical Circulatory Support Devices.- 7. Clinical Requirements for Mechanical Circulatory Support Devices.- 8. Engineering Perspectives for Mechanical Circulatory Support Devices.- Part II: Indications and Selection for Mechanical Circulatory Support.- 9. Patient Population and Selection Criteria for Mechanical Circulatory Support.- 10. Mechanical Circulatory Support Therapies; Right Timing and Prognosis Considerations.- 11. Perioperative Considerations in Left Ventricular Assist Device Placement.- 12. Left Ventricular Assist Devices: Management and Surgical Techniques.- 13. Mechanical Circulatory Support for Biventricular Failure: Patient Selection and Management Options.- 14. Status and Availability of a Total Artificial Heart.- 15. Extracorporeal Membrane Oxygenation Techniques and Modern Considerations.- 16. Less Invasive Extra-Pericardial Placement (LIEPP) of LVAD.- Part III. Parameters of Physiologic and Non-Physiologic Blood Flow.- 17. Pulsatile Mechanical Circulation, Physiology and Pump Technology.- 18. Pathophysiological Determinants Relevant in Blood Pump Control.- 19. End-Organ Physiology under Continuous Flow Mechanical Circulatory Support.- 20. Quantification of Pulsatility during Mechanical Circulatory Support.- 21. Pulsatility as an Option with Continuous-Flow Mechanical Circulatory Support Devices.- Part IV. Current Technology and Methods.- 22. Implantable Continuous-Flow Blood Pump Technology and Features.- 23. Partial Support with Mechanical Circulatory Support Devices.- 24. Percutaneous Mechanical Circulatory Support Technologies.- 25. Computational Fluid Dynamics for Mechanical Circulatory Support Device Development.- 26. Hemodynamic Modelling and Simulations for Mechanical Circulatory Support.- 27. Options for Modeling and Simulations Used in Mechanical Circulatory Support Development.- Part V. Evolving Technologies and Device Concepts.- 28. Emerging Continuous Flow Blood Pump Technologies.- 29. The Development of Advanced Ventricular Assist Device as a Next Generation Ventricular Assist Device.- 30. Cleveland Clinic Total Artificial Heart.- 31. The ReinVAD LVAD - Smart Technology to Enhance Long-Term Circulatory Support Therapy.- 32. EVAHEART 2 Left Ventricular Assist System: A Hemocompatible Centrifugal Pump with Physiological Pulsatility.- 33. A Novel Rotary Total Artificial Heart Using a Single Shuttling Impeller.- 34. New Mechanical Circulatory Device: TORVAD.- 35. BiVACOR Total Artificial Heart.- 36. The Penn State Pediatric Total Artificial Heart.- 37. CorWave LVAD: Insight Into Device Concept And Stage of Development.- 38. Progress on Total Artificial Heart for Pediatric Patients.- 39. Progress on Wireless LVAD and Energy Sources for Mechanical Circulatory Systems.- Part VI. Management Strategies and Limitations of MCS.- 40. Risk Factors for Mechanical Circulatory Support Use and Risk Assessment.- 41. Gastrointestinal Bleeding in Mechanical Circulatory Support Patients.- 42. Postoperative Management Strategies in Mechanical Circulatory Support Patients.- 43. Palliative Care in MCS patients: Insights into Current Practice and Outcomes.- Part VII. Future Perspectives.- 44. Clinical Demands and Challenges for Future Mechanical Circulatory Support Technologies.- 45. Smart Mechanical Circulatory Support Devices:Requirements and Perspectives.- 46. Novel Solutions for Patient Monitoring and Mechanical Circulatory Support Device  Control.