Interaction of Nanomaterials with the Immune System

James C. Bonner is Professor of Toxicology at North Carolina State University. His research focuses on the fibroproliferative effects of nanomaterials in the lung, particularly in susceptible disease models. Jared M. Brown is Professor of Toxicology at the University of Colorado Anschutz Medical Campus. His research focuses on allergic immune responses to nanomaterials and their application in medicine.

Overview of immune response to nanomaterials caused by either inhalation, oral, or dermal exposure.- Engineered nanomaterials: synthesis, characterization, uses and exposure.- Impact of nanomaterials on barrier function.- Complement activation and inflammation.- Macrophage function and phagocytosis.- Mast cells.- Impact on dendritic cell - lymphocyte function.- Impact on host pathogen response and microbiome.- Allergy/autoimmunity.- Pre-existing allergic or bacterial-induced lung disease.- Nanomaterial effects on viral infection.- Immunotoxicity and carcinogenesis.- In vivo animal models (nude mice, transgenic models).- In vitro cell culture models.- In silico computational modeling.- Summary of mechanisms of immune modulation.