Medicinal Chemistry

Rudi van Eldik was born in Amsterdam (The Netherlands) in 1945 and grew up in Johannesburg (South Africa). He received his chemistry education and DSc degree at the former Potchefstroom University (SA), followed by post-doctoral work at the State University of New York at Buffalo (USA) and the University of Frankfurt (Germany). After completing his Habilitation in Physical Chemistry at the University of Frankfurt in 1982, he was appointed as Professor of Inorganic Chemistry at the Private University of Witten/Herdecke in 1987. In 1994 he became Professor of Inorganic and Analytical Chemistry at the University of Erlangen-Nürnberg, from where he retired in 2010. At present he is Professor of Inorganic Chemistry at the Jagiellonian University in Krakow, Poland, and Visiting Professor of Inorganic Chemistry at the N. Copernicus University in Torun, Poland. His research interests cover the elucidation of inorganic and bioinorganic reaction mechanisms, with special emphasis on the application of high pressure thermodynamic and kinetic techniques. In recent years his research team also focused on the application of low-temperature rapid-scan techniques to identify and study reactive intermediates in catalytic cycles, and on mechanistic studies in ionic liquids. He is Editor of the series Advances in Inorganic Chemistry since 2003. He serves on the Editorial Boards of several chemistry journals. He is the author of over 880 research papers and review articles in international journals and supervised 80 PhD students. He has received honorary doctoral degrees from the former Potchefstroom University, SA (1997), Kragujevac University, Serbia (2006), Jagiellonian University, Krakow, Poland (2010), University of Pretoria, SA (2010), and Ivanovo State University of Chemistry and Technology, Russia (2012). He has developed a promotion activity for chemistry and related experimental sciences in the form of chemistry edutainment presentations during the period 1995-2010. In 2009 he was awarded the Federal Cross of Merit (‘Bundesverdienstkreuz’) by the Federal President of Germany, and the Inorganic Mechanisms Award by the Royal Society of Chemistry (London). His hobbies include music, hiking, jogging, cycling and motor-biking. He is the father of two and grandfather of four children. Peter Sadler, is at Warwick University, UK

1. 150 Years of the periodic table: New medicines and diagnostic agents Cinzia Imberti and Peter J. Sadler 2. Medicinal inorganic chemistry: New perspectives and targets for the periodic table Nicholas P. Farrell 3. Anti-cancer gold, platinum and iridium compounds with porphyrin and/or N-heterocyclic carbene ligand(s) Ka-Chung Tong, Di Hu, Pui-Ki Wan, Chun-Nam Lok and Chi-Ming Che 4. Metal N-heterocyclic carbene complexes in medicinal chemistry Ingo Ott 5. Rational design of anticancer platinum(IV) prodrugs Shuren Zhang, Xiaoyong Wang and Zijian Guo 6. Bismuth drugs as antimicrobial agents Runming Wang, Hongyan Li, Tiffany Ka-Yan Ip and Hongzhe Sun 7. Antimony and bismuth as antimicrobial agents Rebekah N. Duffin, Melissa V. Werrett and Philip C. Andrews 8. Pharmacophore conjugation strategy for multi-targeting metal-based anticancer complexes Yao Zhao, Yan Kang, Fengmin Xu, Wei Zheng, Qun Luo, Yanyan Zhang, Feifei Jia and Fuyi Wang 9. Organelle-targeting metal anticancer agents Lina Xie, Ruilin Guan, Thomas W. Rees and Hui Chao 10. From the hypothesis-driven development of organometallic anticancer drugs to new methods in mode of action studies Muhammad Hanif and Christian G. Hartinger 11. Design and applications of catalytic metallodrugs containing the ATCUN motif Zhen Yu and James A. Cowan 12. The eyes have it: Using X-ray crystallography to determine the binding modes of medically relevant ruthenium/DNA complexes Kane Thomas McQuaid and Christine Janet Cardin 13. Interaction of metal complexes with G-quadruplex DNA Ramon Vilar 14. CXCR4-targeted metal complexes for molecular imaging Isaline Renard and Stephen J. Archibald