Chemical & Biological Aspects of Drug Dependence

S. J. Mule, H. Brill

Introduction. 3.  Significance and Characteristics of Drug Dependence.  Characteristics of Dependence on and Abuse of Psychoactive Drugs. 13.  Characteristics of Drug Dependence To:  Narcotic Analgesics and Antagonist. 25.  Barbiturates, Alcohol, and Tranquilizers. 37.  CNS Stimulants and Hallucinogens. 55.  Cannabis. 65.  Criteria for Evaluating Drug Dependence.  Criteria for Evaluating Physical and Psychic Dependence and Overall Abuse Potential of Drugs in Man. 85.  Chemical Aspects of Drug Dependence.  Chemical Characteristics of Drugs Inducing Physical and/or Psychic Dependence to:  Narcotic Analgesics and Antagonists. 101.  Barbiturates and Minor Tranquilizers. 119.  Alcohol. 135.  Hallucinogens, CNS Stimulants, and Cannabis. 163.  Interaction of Drugs of Dependence with Receptors. 177.  Disposition and Metabolism of Drugs of Dependence. 219.  Detection and Identification of Drugs of Dependence. 277.  Physiologic and Pharmacologic Aspects of Drug Dependence.  Characteristics and Theories Related to Acute and Chronic Tolerance Development. 307.  Theories Related to Physical Dependence. 359.  Electrophysiology of Drugs Dependence. 379.  Neuropathology of Drugs Dependence. 389.  Teratogenicity, Embryolethality, and Mutagenicity of Drugs of Dependence. 413.  Biochemical Aspects of Drug Dependence.  Enzymes. 449.  Proteins and Nucleic Acids. 465.  Carbohydrates. 477.  Neurotransmitters and the Narcotics Analgesics. 495.  Lipids. 505.  Hormones. 523.  Theoretical Biochemical Mechanisms for Drug Dependence. 545.  Index. 563.