Computational Systems Biology Approaches in Cancer Research

Inna Kuperstein is a researcher at Institut Curie, Paris, France, she is a coordinator of the Atlas of Cancer Signalling Networks (ACSN) project for construction and analysis of detailed signalling maps, development of tools and modelling the maps to predict drug response. She participates in multidisciplinary projects to decipher cell mechanisms rewiring in cancer. Emmanuel Barillot is the head of the Cancer and Genome: Bioinformatics, Biostatistics and Epidemiology of a Complex System department and scientific director of the bioinformatics platform at Institut Curie. His research focuses on methodological development and statistical analysis of high-throughput biological data and modeling with the aim to improve therapeutic treatments of cancer.

Pathway Databases and Network Resources in Cancer. Signor and Disnor – Causal Interaction Networks for Disease Analysis. Reactome: A Free and Reliable Database to Analyze Biological Pathways. Atlas of Cancer Signalling Network: An Encyclopedia of Knowledge on Cancer Molecular Mechanisms. Tumour Microenvironment Studies in Immuno-Oncology Research. Network Analysis of the Immune Landscape of Cancer. Integrative Cancer Immunology and Novel Concepts of Cancer Evolution. Systems Biology Approach to Study Heterogeneity and Cell Communication Networks in the Tumour Microenvironment. Tools and Approaches. The Cytoscape Platform for Network Analysis and Visualization. Disease Perception: Personalized Comorbidity Exploration. Deconvolution of Heterogeneous Cancer Omics Data. Mathematical Modelling of Signalling Networks in Cancer. Qualitative Dynamical Modelling of T-Helper Cell Differentiation and Reprogramming. Mathematical Models of Signalling Pathways and Gene Regulation Involved in Cancer. Dynamic Logic Models Complement Machine Learning to Improve Cancer Treatment. Framework for High-Throughput Personalization of Logical Models Using Multi-Omics Data. Single-Cell Analysis in Cancer. Tracing Stem Cell Differentiation with Single-Cell Resolution. Phylogeny-Guided Single-Cell Mutation Calling. Patient Stratification and Treatment Response Prediction. Integrative Network-Based Analysis for Subtyping and Cancer Driver Identification. Patient Stratification from Somatic Mutations. Evaluating Growth and Risk of Relapse of Intracranial Tumours. Machine Learning for Systems Microscopy.