Immunopathology in Toxicology and Drug Development
Springer International Publishing (Verlag)
978-3-319-83726-0 (ISBN)
This book provides a fundamental understanding of immunopathology and immunopathologic processes, with particular attention to nonclinical toxicology studies. Chapters provide organ system-based summaries of spontaneous pathology and common responses to xenobiotics. A companion volume, Immunopathology in Toxicology and Drug Development: Volume 1, Immunobiology, Investigative Techniques, and Special Studies, offers an overview of general immunobiology, cells of the immune system, signaling and effector molecules, and immunopathology assays.
These informative and strategic books were created in response to the large segment of drug development that focuses on chronic diseases, many of which involve alterations to the immune system. Therapies that target these diseases commonly involve some form of immunomodulation. As a result, the two volumes of Immunopathology in Toxicology and Drug Development are critical texts for individuals involved in diverse aspects ofdrug development. Readers will acquire a thorough understanding of immunopathology for detection and accurate interpretation of pathologic effects of xenobiotics on the immune system.
George A. Parker, a leading expert in the field of toxicologic pathology, is currently a Senior Scientific Director, Global Pathology, at Charles River Laboratories. Dr. Parker is a graduate of Auburn University College of Veterinary Medicine and completed a residency program in veterinary pathology at the Armed Forces Institute of Pathology, as well as a Ph.D. program in molecular and cellular immunology at the University of Medicine and Dentistry of New Jersey. He is a board-certified pathologist and toxicologist as well as a fellow of the distinguished International Academy of Toxicologic Pathology. He has more than 35 years of experience in the field of toxicologic pathology, with an emphasis on the nonclinical safety assessment of drugs, agricultural chemicals, and industrial chemicals. Dr. Parker's areas of specific expertise include immunopathology, toxicologic pathology of juvenile animals, and radiation pathology.
Thymus.- Spleen.- Lymph node.- Mucosa-associated lymphoid tissues.- Immunopathology of the nervous system.- Immunopathology of the urinary system.- Immunopathology of the hepatobiliary system.- Immunopathology of the respiratory system.- Immunopathology of the cardiovascular system.- Immunopathology of the male reproductive tract.- Immunopathology of the female reproductive tract and mammary gland.- Immunopathology of the musculoskeletal system.- Immunopathology of the endocrine system.- Ocular Immunopathology.- Immunopathology of Drug and Toxin-related Skin Reactions.
"The purpose is to provide organ system-based summaries of spontaneous pathology and common responses to xenobiotics. ... used as a textbook or reference for students, as an informative resource for novices in the field, and as a reference for researchers in the immune toxicology field. It also can be educational for the lay public who are interested in learning immunopathology in xenobiotics or general basic immunology. ... a terrific book that I will certainly integrate into my graduate teaching." (Hongmin Ni, Doody's Book Reviews, November, 2017)
| Erscheinungsdatum | 08.02.2019 |
|---|---|
| Reihe/Serie | Molecular and Integrative Toxicology |
| Zusatzinfo | XXII, 826 p. 255 illus., 250 illus. in color. |
| Verlagsort | Cham |
| Sprache | englisch |
| Maße | 155 x 235 mm |
| Gewicht | 1710 g |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete |
| Medizin / Pharmazie ► Pharmazie | |
| Studium ► 2. Studienabschnitt (Klinik) ► Pathologie | |
| Studium ► Querschnittsbereiche ► Infektiologie / Immunologie | |
| Technik | |
| Schlagworte | drug development • histogenesis • Immunomodulation • immunopathology • xenobiotic exposure |
| ISBN-10 | 3-319-83726-5 / 3319837265 |
| ISBN-13 | 978-3-319-83726-0 / 9783319837260 |
| Zustand | Neuware |
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