Bayesian Adaptive Designs for Innovative Clinical Trials and Precision Medicine
Seiten
2023
Apple Academic Press Inc. (Verlag)
978-1-4822-1806-0 (ISBN)
Apple Academic Press Inc. (Verlag)
978-1-4822-1806-0 (ISBN)
Features novel topics that provide different angles and fresh ideas. For example, mTPI is based on a different statistical framework than most current adaptive designs for phase I dose finding trials. The phase I-II seamless design is also fresh with few publications
Covers the adaptive subgroup discovery which is trendy, given the recent advance in genomics medicine. It is also highly important to improve the efficiency of the new types of biomarker trials aiming to identify subgroups that have high risks of disease progression or high probabilities of response
Discusses some recently debated issues that will stimulate more research and advancement in the adaptive designs. For example, the issue of borrowing strength in phase I dose-finding trials
Covers the adaptive subgroup discovery which is trendy, given the recent advance in genomics medicine. It is also highly important to improve the efficiency of the new types of biomarker trials aiming to identify subgroups that have high risks of disease progression or high probabilities of response
Discusses some recently debated issues that will stimulate more research and advancement in the adaptive designs. For example, the issue of borrowing strength in phase I dose-finding trials
Introduction to Bayes. Phase I Dose-Finding Designs. Phase I Designs Based on Toxicity. Phase I/II Designs Based on Joint Efficacy/Toxicity. Adaptive Dose Insertion. Phase II Trial Designs. Optimal and Minimax Two-Stage Designs. Bayesian Adaptive Designs. Seamless Designs. Phase I-II Seamless Designs. Phase II-III Seamless Designs. Some Practical Considerations. Borrowing Strength in Phase I Trials. the Necessity of Phases. Adaptive Learning to Speed Up Phase III. Change of Models for Early Phase Designs.
| Reihe/Serie | Chapman & Hall/CRC Biostatistics Series |
|---|---|
| Zusatzinfo | 200 Illustrations, black and white |
| Verlagsort | Oakville |
| Sprache | englisch |
| Maße | 156 x 234 mm |
| Themenwelt | Studium ► Querschnittsbereiche ► Epidemiologie / Med. Biometrie |
| Naturwissenschaften ► Biologie | |
| Technik | |
| ISBN-10 | 1-4822-1806-2 / 1482218062 |
| ISBN-13 | 978-1-4822-1806-0 / 9781482218060 |
| Zustand | Neuware |
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Buch | Hardcover (2024)
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