Metal-Carbon Bonds in Enzymes and Cofactors (eBook)

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Helmut und Astrid Sigel, University of Basel, Switzerland. Roland K. O. Sigel, University of Zürich, Switzerland.

From the Content:

•Organometallic Chemistry of B12 Coenzymes
•Cobalamin- and Corrinoid-Dependent Enzymes
•Nickel-Alkyl Bond Formation in the Active Site of Methyl-Coenzyme M Reductase
•Nickel-Carbon Bonds in Acetyl-Coenzyme A Synthases/Carbon Monoxide Dehydrogenases
•Structure and Function of [NiFe]-Hydrogenases
•Carbon Monoxide and Cyanide Ligands in the Active Site of [FeFe]-Hydrogenases
•Carbon Monoxide as Intrinsic Ligand to Iron in the Active Site of [Fe]-Hydrogenase
•The Dual Role of Heme as Cofactor and Substrate in the Biosynthesis of Carbon Monoxide
•Copper-Carbon Bonds in Mechanistic and Structural Probing of Proteins as well as in Situations where Copper Is a Catalytic or Receptor Site
•Interaction of Cyanide with Enzymes Containing Vanadium, Manganese, Non-Heme Iron, and Zinc
•The Reaction Mechanism of the Molybdenum Hydroxylase Xanthine Oxidoreductase: Evidence Against the Formation of Intermediates Having Metal-Carbon Bonds
•Computational Studies of Biooganometalllic Enzymes and Cofactors