Endoscopic Fibrin Gluing

This text looks at the technique of injecting fibrin glue to inhibit bleeding ulcers.

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The goal of interventional endoscopy is to definitively stop the bleeding and at the same time promote the healing of life-threatening bleeding ulcers. Up until now, however, this goal has not been fully achieved. The breakthrough came only with the submucousal (or subulcerous) injection of highly concentrated fibrinogen and thrombin, fibrin glue. Upon mixing, both substances initiate phase 3 in the blood clotting reaction. A mechanically strong and stable "fibrin clot" is produced which is strongly anchored into the tissue and not only seals the vessel, but also induces the tissue repair mechanisms. Due to the "bio-identical" properties of the procedure the injection, in contrast to the other injection methods, can be harmlessly repeated as often as required in order to achieve an especially favourable and stable distribution of the glue. On top of this, the property of being non-harmful to tissue allowed the development of a comprehensive therapy system utilising submucousal fibrin gluing. Within the realms of a close-knit series of control endoscopy examinations the regluing can be performed as often as necessary.
This occurs in the case of persistent bleeding stigmata but also prophylactically in non-bleeding cases and therefore, a real chance exists of preventing a relapse in bleeding.